4-Bromomethyl-1,2-dihydroquinoline-2-one synthesis
- Product Name:4-Bromomethyl-1,2-dihydroquinoline-2-one
- CAS Number:4876-10-2
- Molecular formula:C10H8BrNO
- Molecular Weight:238.08
1205-74-9
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4876-10-2
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Yield:4876-10-2 95.08%
Reaction Conditions:
with phosphorus pentoxide at 83; for 13 h;Flow reactor;Large scale;Solvent;
Steps:
1 Example 1
In the 5000L enamel reactor,After 4000 kg of dichloroethane was charged,500 kg of acetoacetanilide bromide,Stirring evenly;At the same time in another 2000L reactor in 1000 kg of dichloroethane and 1000 kg of phosphorus pentoxide,Began at the same time will 5000L reactor and 2000L reactor temperature to dichloroethane reflux,The reaction temperature was 83 .After refluxing for one hour,5000L distillation reactor out of the dichloroethane condensate into the 2000L reactor,2000L reactor dehydration distillation of dichloroethane condensate into the 5000L reactor,Control two kettle distillation speed synchronization;After 12 hours of reaction,Cooling to room temperature;The 4-bromomethylquinolinone was separated by a filter press,The 4-bromomethylquinolinone was further washed with dichloroethane,And then through the filter press after separation,The obtained wet product containing dichloroethane solvent was vacuum dried,442 kg of white powdery solid;The yield was 95.08% and the purity was 99.67% (HPLC).
References:
Chen, Ke;Wu, Xiongfei CN105753781, 2016, A Location in patent:Paragraph 0016; 0017
102-01-2
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4876-10-2
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62-53-3
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4876-10-2
291 suppliers
$5.00/5g