4-OXO-4-THIOPHEN-2-YL-BUTYRIC ACID ETHYL ESTER synthesis

6synthesis methods

Product Name:4-OXO-4-THIOPHEN-2-YL-BUTYRIC ACID ETHYL ESTER
CAS Number:59086-25-8
Molecular formula:C10H12O3S
Molecular Weight:212.27

188290-36-0 Synthesis

188290-36-0
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14794-31-1 Synthesis

14794-31-1
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$9.00/25g

4-OXO-4-THIOPHEN-2-YL-BUTYRIC ACID ETHYL ESTER

59086-25-8
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Yield:59086-25-8 93%

Reaction Conditions:

with tin(IV) chloride in dichloromethane at 20; for 2 h;Cooling;

Steps:

9 [Synthesis of A2-1-1]

To a dichloromethane solution (150 mL) of thiophene (9.20 g, 109 mmol) and ethyl 4-chloro-4-oxobutyrate (18.0 g, 109 mmol), tin(IV) chloride (12.9 mL, 109 mmol) was added dropwise under ice cooling. The reaction solution was stirred at room temperature for 2 hours, then poured into ice water, and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain A2-1-1 (21.6 g, 102 mmol, 93% yield).

References:

US2021/71004,2021,A1 Location in patent:Paragraph 0192-0193

4653-08-1 Synthesis