(4-TERT-BUTYLPHENYL)THIO]ACETIC ACID synthesis

5synthesis methods

Product Name:(4-TERT-BUTYLPHENYL)THIO]ACETIC ACID
CAS Number:4365-63-3
Molecular formula:C12H16O2S
Molecular Weight:224.32

79-11-8
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$27.00/25g

2396-68-1 Synthesis

2396-68-1
196 suppliers
$8.00/1g

4365-63-3
12 suppliers
$28.60/25mg

Yield:-

Reaction Conditions:

with sodium hydroxide at 120 - 130; for 5 h;

Steps:

Materials

General procedure: Phenylsulfinylacetic acid and several para- and meta substituted phenylsulfinyl acetic acids were prepared from the corresponding phenylmercaptoacetic acids by controlled oxidation using equimolar quantity of H₂O₂ and recrystallised from suitable solvents. The recrystallised phenylsulfinylacetic acids were dried, melting points were determined and checked with the literature values. Thepurity was also ascertained by LC-MS for all the phenylsulfinylacetic acids. Then they were stored in the vacuum desiccator and used for the kinetic studies. Phenylmercaptoacetic acids required for the synthesis of PSAAs were synthesized by condensing chloroacetic acid (4.7 g in 20 ml of 20% sodium hydroxide) with appropriate thiophenol (0.05 mole) dissolved in 10 ml of 20% sodium hydroxide at 120-130°C for five hours. The phenylmercaptoacetic acids formed were recrystallised from water and their melting points were verified with the literature values.32 Potassium dichromate (Merck), sodium perchlorate (Merck), perchloric acid (Merck) and all other reagents used were of AnalaR grade. Solvents, acetonitrile and water were purified by established procedures.

References:

Subramaniam, Perumal;Selvi, Natesan Thamil;Devi, Soundarapandian Sugirtha [Journal of the Korean Chemical Society,2014,vol. 58,# 1,p. 17 - 24]

79-08-3 Synthesis