ChemicalBook CAS DataBase List 5-Bromo-2-methoxypyrimidine

5-Bromo-2-methoxypyrimidine synthesis

6synthesis methods

Product Name:5-Bromo-2-methoxypyrimidine
CAS Number:14001-66-2
Molecular formula:C5H5BrN2O
Molecular Weight:189.01

124-41-4 Synthesis

124-41-4
670 suppliers
$12.00/25g

32779-36-5 Synthesis

32779-36-5
611 suppliers
$5.00/5g

14001-66-2
243 suppliers
$7.00/1g

Yield:14001-66-2 60%

Reaction Conditions:

with methanol at 70;

Steps:

1
Synthesis of Compound 11-3 (0400) To a solution of 11-2 (2.0 g, 10 mmol) in methanol (15 mL) was added CH₃ONa (2.16 g, 40 mmol). The resulting mixture was stirred at 70° C. overnight. Methanol was evaporated in vacuum. Water (10 mL) was added carefully to the residue and the mixture was extracted with ethyl acetate (300 mL×3). The combined organic layers were dried over Na₂SO₄, filtered and concentrated to afford 11-3 as a yellow solid (1.17 g, 60%).

References:

Nivalis Therapeutics, Inc.;Wasley, Jan;Rosenthal, Gary J.;Sun, Xicheng;Strong, Sarah;Qiu, Jian US9138427, 2015, B2 Location in patent:Page/Page column 289-290

FullText

67-56-1 Synthesis