ChemicalBook CAS DataBase List 3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid

3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid synthesis

4synthesis methods

Product Name:3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid
CAS Number:94022-99-8
Molecular formula:C10H9F3O2
Molecular Weight:218.17

64-18-6 Synthesis

64-18-6
1060 suppliers
$22.12/250ML

447-61-0 Synthesis

447-61-0
317 suppliers
$9.00/10g

3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid

94022-99-8
130 suppliers
$6.00/250mg

Yield: 14.3 g

Reaction Conditions:

with cycl-isopropylidene malonate;triethylamine at 100; for 2.5 h;Cooling with ice;

Steps:

45.B
The triethylamine was cooled in a 27 ml ice bath, then 18.5 ml of formic acid was added dropwise, followed by o-trifluoromethylbenzaldehyde (10.5 g, 60.3 mmol) and2,2-Dimethyl-1,3-dioxane-4,6-dione (10.0 g, 69.4 mmol),The reaction was refluxed at 100 °C for 2.5 hours. After the reaction was cooled to room temperature, water (100 ml) was added, the pH was adjusted to 3 with 2N hydrochloric acid, and the mixture was evaporated.Drying in vacuo gave 14.3 g of the solid, o-trifluoromethylbenzenepropionic acid.

References:

Chongqing Pharmaceutical Industry Institute Co., Ltd.;Xu Liyan;Liao Yong;Liu Caiping;Lei Huangshu;Deng Jie;Zou Yanye;Lei Wenbo;Zhou Changbing;He Zhiqin;Wu Kuncan;Yuan Quan;Fan Bin CN109422749, 2019, A Location in patent:Paragraph 0452; 0456

98386-81-3 Synthesis