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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Benzocaine hydrochloride

Benzocaine hydrochloride synthesis

5synthesis methods
Benzocaine hydrochloride is a topical anesthetic that works by blocking impulse propagation along nerve fibers and at nerve endings. P-nitrotoluene in sulfuric acid is oxidized with sodium dichromate to generate p-nitrobenzoic acid, which is esterified with ethanol.  The reaction is completed to give ethyl p-nitrobenzoate. Benzocaine is synthesized by iron powder was added ethyl p-nitrobenzoate in acetic acid with reducing reaction at 85～95℃.
94-09-7 Synthesis
Benzocaine

94-09-7
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Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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Benzocaine hydrochloride

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-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: bromine; acetic acid; triethylamine / 2 h / 20 °C
2: hydrogenchloride / ethyl acetate

References:

Takeda Pharmaceutical Company Limited EP1726580, 2006, A1

Ethyl p-nitrobenzoate

99-77-4
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$12.00/1mg

Benzocaine hydrochloride

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References
7149-03-3 Synthesis
4-AMINO-3-BROMO-BENZOIC ACID ETHYL ESTER

7149-03-3
83 suppliers
$37.00/1g

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
0 suppliers
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Benzocaine hydrochloride

23239-88-5
220 suppliers
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References
64-17-5 Synthesis
Ethanol

64-17-5
693 suppliers
$10.00/50g

150-13-0 Synthesis
4-Aminobenzoic acid

150-13-0
876 suppliers
$5.00/25g

Benzocaine hydrochloride

23239-88-5
220 suppliers
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References
94-09-7 Synthesis
Benzocaine

94-09-7
769 suppliers
$5.00/50mg

Benzocaine hydrochloride

23239-88-5
220 suppliers
inquiry

References

Benzocaine hydrochloride Related Search:

Ethyl formate Methoxyammonium chloride Ethyl acetate Triethylamine hydrochloride 2-Phenylethylamine hydrochloride Benzocaine Glycine ethyl ester hydrochloride 4-Aminobenzoic acid Ethyl benzoate Ethanol