ChemicalBook CAS DataBase List Dimethyl 2,4-pyridinedicarboxylate

Dimethyl 2,4-pyridinedicarboxylate synthesis

6synthesis methods

Product Name:Dimethyl 2,4-pyridinedicarboxylate
CAS Number:25658-36-0
Molecular formula:C9H9NO4
Molecular Weight:195.17

67-56-1 Synthesis

67-56-1
734 suppliers
$9.00/25ml

499-80-9 Synthesis

499-80-9
288 suppliers
$8.00/1g

25658-36-0
65 suppliers
$45.00/50mg

Yield:25658-36-0 98%

Reaction Conditions:

with thionyl chloride for 5 h;Reflux;

Steps:

3.3 5.1.2.4 Preparation of dimethyl [2,2'-bipyridine]-4,4'-dicarboxylate (17)

General procedure: Thionyl chloride (300μL, 4.08mmol) was added to a suspension of 16 (400mg, 1.62mmol) in MeOH (30mL) in a dropwise fashion.
The mixture was heated at reflux temperature overnight.
Then, the solvent was removed under reduced pressure and the residue was partitioned between CH₂Cl₂ and water.
The organic layer was washed with saturated aqueous NaHCO₃ solution and dried over Na₂SO₄.
Filtration, evaporation in vacuo, and recrystallization in AcOEt gave 17 (400mg, 91%)

References:

Miyake, Yuka;Itoh, Yukihiro;Hatanaka, Atsushi;Suzuma, Yoshinori;Suzuki, Miki;Kodama, Hidehiko;Arai, Yoshinobu;Suzuki, Takayoshi [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 6,p. 1119 - 1129]

499-80-9 Synthesis

499-80-9
288 suppliers
$8.00/1g

149-73-5 Synthesis