ChemicalBook CAS DataBase List ETHYL 6-AMINOHEXANOATE

ETHYL 6-AMINOHEXANOATE synthesis

10synthesis methods

Product Name:ETHYL 6-AMINOHEXANOATE
CAS Number:371-34-6
Molecular formula:C8H17NO2
Molecular Weight:159.23

6-AMINOCAPRONIC ACID ETHYL ESTER HYDROCHLORIDE

3633-17-8
58 suppliers
$65.00/1g

371-34-6
19 suppliers
$59.89/250mg

Yield:371-34-6 98.9%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 20; for 12.5 h;

Steps:

1.2 2) Preparation of Ethyl 6-Aminohexanoate

After 340.0 g (1.74 mol) of the ethyl 6-aminohexanoate hydrochloride prepared in 1) was put in a 2 L round-bottom flask and 700 ml of dichloromethane was added thereto, the temperature was set at 0° C. Thereafter, a reaction was performed for 12 hours by slowly increasing the temperature to room temperature while 605.86 ml (4.34 mol) of triethylamine was slowly added for 30 minutes, and the reaction was then terminated. After 500 ml of water was added to extract an organic layer, sodium sulfate was added to the organic layer, filtered, and then concentrated to obtain 273.7 g (yield: 98.9%) of ethyl 6-aminohexanoate. 1H nuclear magnetic resonance spectroscopic data of the ethyl 6-aminohexanoate are as follows. (0182) ¹H-NMR (500 MHz, CDCl₃) δ 4.13-4.09 (q, 2H), 2.69-2.67 (t, 2H), 2.30-2.27 (t, 2H), 1.60 (m, 2H), 1.48-1.42 (m, 2H), 1.37-1.31 (m, 2H), 1.25-1.23 (t, 2H), 1.19 (s, 3H).

References:

US2020/123287,2020,A1 Location in patent:Paragraph 0180-0182