METHYL 2-FLUORO-4-HYDROXYBENZOATE synthesis
- Product Name:METHYL 2-FLUORO-4-HYDROXYBENZOATE
- CAS Number:197507-22-5
- Molecular formula:C8H7FO3
- Molecular Weight:170.14
67-56-1
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65145-13-3
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197507-22-5
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$6.00/100mg
Yield: 94%
Reaction Conditions:
with sulfuric acid at 90; for 16 h;
Steps:
10
Reference Example 10; methyl 2-fluoro-4-hydroxybenzoate A solution of 2-fluoro-4-hydroxybenzoic acid (50.0 g) and concentrated sulfuric acid (10 mL) in methanol (700 mL) was stirred at 90°C for 16 hr with heating. The reaction solution was concentrated, and the resulting colorless crystals were washed with water, and dried to give the title compound (51 g, yield 94%) as colorless crystals. 1H NMR (300 MHz, DMSO-d6) 5: 3.79 (3 H, s), 6.61 - 6.72 (2 H, m), 7. 73 - 7.79 (1 H, m), 10.80 (1 H, br).
References:
Takeda Pharmaceutical Company Limited EP2392573, 2011, A1 Location in patent:Page/Page column 39
179232-29-2
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197507-22-5
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$6.00/100mg
65145-13-3
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$10.00/1g
197507-22-5
106 suppliers
$6.00/100mg
65145-13-3
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18107-18-1
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197507-22-5
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331-64-6
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$14.00/1g
197507-22-5
106 suppliers
$6.00/100mg