(TRIMETHYLSILYL)DIAZOMETHANE
- CAS No.
- 18107-18-1
- Chemical Name:
- (TRIMETHYLSILYL)DIAZOMETHANE
- Synonyms
- TMSCHN2;TMS-DIAZOMETHANE;(DIAZOMETHYL)TRIMETHYLSILANE;(trimethylsilyl)diazomethanesolution;2.0 M in hexanes;ACROS Organics™TriMethylsilyl)diazoMethan;iazomethyl(trimethyl)silane;(TRIMETHYLSILYL)DIAZOMETHANE;Diazo(trimethylsilyl)methane
- CBNumber:
- CB9432840
- Molecular Formula:
- C4H10N2Si
- Molecular Weight:
- 114.22
- MDL Number:
- MFCD00053946
- MOL File:
- 18107-18-1.mol
- MSDS File:
- SDS
| Boiling point | 96 °C |
|---|---|
| Density | 0.773 g/mL at 25 °C |
| refractive index | 1.4362 |
| Flash point | −31 °F |
| storage temp. | Refrigerator |
| solubility | Sol most organic solvents; insol H2O. |
| form | Solution |
| color | White |
| Water Solubility | Immiscible with water. Miscible with organic solvents. |
| Sensitive | Moisture & Light Sensitive |
| BRN | 1902903 |
| Stability | Shock Sensitive |
| CAS DataBase Reference | 18107-18-1(CAS DataBase Reference) |
| FDA UNII | QI98HQO8C4 |
| EPA Substance Registry System | Silane, (diazomethyl)trimethyl- (18107-18-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H331-H361-H225-H304-H315-H330-H336-H350-H361f-H370-H373-H411-H302 | |||||||||
| Precautionary statements | P201-P210-P280-P308+P311-P370+P378-P403+P235-P260-P301+P310a-P303+P361+P353-P405-P501a | |||||||||
| Hazard Codes | F+,Xn,N,F,T,T+ | |||||||||
| Risk Statements | 12-19-22-66-67-65-62-51/53-48/20-38-11-23-39/26-26-45 | |||||||||
| Safety Statements | 9-16-29-33-36/37-61-62-45-28-53 | |||||||||
| RIDADR | UN 1208 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29270000 | |||||||||
| NFPA 704 |
|
(TRIMETHYLSILYL)DIAZOMETHANE price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T1146 | Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L) | 18107-18-1 | 10mL | $105 | 2024-03-01 | Buy |
| TCI Chemical | T1146 | Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L) | 18107-18-1 | 25mL | $210 | 2024-03-01 | Buy |
| Alfa Aesar | H26744 | (Trimethylsilyl)diazomethane, 2M in hexanes | 18107-18-1 | 25ml | $204 | 2021-12-16 | Buy |
| Alfa Aesar | H26744 | (Trimethylsilyl)diazomethane, 2M in hexanes | 18107-18-1 | 5ml | $62.2 | 2021-12-16 | Buy |
| Sigma-Aldrich | 527254 | (Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether | 18107-18-1 | 1l | $3240 | 2023-01-07 | Buy |
(TRIMETHYLSILYL)DIAZOMETHANE Chemical Properties,Uses,Production
Chemical Properties
clear yellow solution
Physical properties
bp 96 °C/775 mmHg; nD/25 1.4362.2
Uses
Trimethylsilyldiazomethane is used as one-carbon homologation reagent; stable, safe substitute for diazomethane;participating in the synthesis reactions of insertion reactions;ketenylation reactions;preparation of homoallylic sulfides;pericyclic reactions;[C-N-N] 1,3-dipole for the preparation of azoles.
Uses
Reactant for preparation of: &bull Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity &bull Aigialomycin D analogues as protein kinase inhibitors for cancer treatment &bull Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction &bull Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates &bull Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity &bull Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach &bull Ent-kaurene derivatives as anti-inflammatory agents &bull Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint &bull Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors
Uses
(Trimethylsilyl)diazomethane is used as an analyte in the determination of some phenolic organohalogens in human serum by GC-MS.
Preparation
Trimethylsilyldiazomethane is prepared by the diazo-transfer reaction of trimethylsilylmethylmagnesium chloride with diphenyl phosphorazidate (DPPA) (eq 1).
General Description
(Trimethylsilyl)diazomethane is considered as a non-explosive substitute to diazomethane for the homologation of carbonyl derivatives, mainly ketones, via reactions such as Tiffeneau-Demjanov rearrangement.
(TRIMETHYLSILYL)DIAZOMETHANE Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15933 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7019 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from (TRIMETHYLSILYL)DIAZOMETHANE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | (Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether
18107-18-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | (TRIMETHYLSILYL)DIAZOMETHANE
18107-18-1
|
US $1.00 / KG | 1G | 99% | 100kg | Career Henan Chemical Co |
-
- (Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether
18107-18-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (TRIMETHYLSILYL)DIAZOMETHANE
18107-18-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co