ChemicalBook CAS DataBase List N-Methylacetamide

N-Methylacetamide synthesis

11synthesis methods

Product Name:N-Methylacetamide
CAS Number:79-16-3
Molecular formula:C3H7NO
Molecular Weight:73.09

Af-Methylacetamide has been prepared by reaction of methylamine with hot acetic acid (D'Alelio and Reid, 1937) and with acetic anhydride (Mauger and Soper, 1946). Other methods include heating iV,N-dimethylurea with acetic acid (US Patent, 1936) and reduction/hydrogenation of N-(hydroxymethyl)acetamide (US Patent, 1944).

1445-45-0 Synthesis

1445-45-0
336 suppliers
$10.00/5mL

593-51-1 Synthesis

593-51-1
527 suppliers
$21.00/100g

79-16-3
306 suppliers
$8.00/25g

Yield:79-16-3 100%

Reaction Conditions:

in methanol at 135; for 0.25 h;Microwave irradiation;

Steps:

General procedure for the preparation of acetamides 3a-3u (via microwave irradiation)
General procedure: To a solution of 1.5 eq trimethyl orthoacetate in 2 mL MeOH was added amine hydrochloride (0.0015 mol). After heating via microwave irradiation to 135°C for 15 minutes, the product was isolated by concentration in vacuo to give essentially pure acetamides. In general, these reactions were accompanied by an expected but slight increase in pressure - none exceeded the pressure limits of the instrument.

References:

Di Grandi, Martin J.;Bennett, Caitlin;Cagino, Kristen;Muccini, Arnold;Suraci, Corey;Saba, Shahrokh [Synthetic Communications,2015,vol. 45,# 22,p. 2601 - 2607] Location in patent:supporting information

64-19-7 Synthesis