N-phenyl-3-(trifluoromethyl)aniline synthesis
- Product Name:N-phenyl-3-(trifluoromethyl)aniline
- CAS Number:101-23-5
- Molecular formula:C13H10F3N
- Molecular Weight:237.22
Yield: 94%
Reaction Conditions:
with potassium carbonate in water at 20; for 5 h;
Steps:
Preparation of diphenylamine; typical procedure
General procedure: To a stirred solution of phenylboronic acid (1.0 mmol), aniline (1.0 mmol), and K2CO3 (2.0 mmol) in deionized H2O (10 mL) at room temperature was added an aqueous suspension of FePd nanowires (3.0 mol % in 3 mL of H2O). The mixture was stirred at room temperature for 5h. After completion of the reaction (as monitored by TLC), 2 M HCl was added and the catalyst was separated by applying an external magnet. The catalyst was washed with EtOAc. The mixture was extracted with EtOAc (2 * 20 mL), dried, and concentrated. The residue was subjected to gel permeation chromatography to afford pure product.
References:
Nasrollahzadeh, Mahmoud;Azarian, Abbas;Ehsani, Ali;Zahraei, Ali [Tetrahedron Letters,2014,vol. 55,# 17,p. 2813 - 2817]
