Trimetazidine synthesis
- Product Name:Trimetazidine
- CAS Number:5011-34-7
- Molecular formula:C14H22N2O3
- Molecular Weight:266.34
1133-49-9
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57260-71-6
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5011-34-7
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$252.00/500mg
Yield:5011-34-7 92.1%
Reaction Conditions:
Stage #1:2,3,4-trimethoxybenzyl chloride;1-t-Butoxycarbonylpiperazine with methanol;sodium hydroxide at 35 - 45; for 4 h;
Stage #2: with hydrogenchloride in water at 35 - 45; for 2 h;
Steps:
1 Preparation of 1-(2,3,4-trimethoxybenzyl)piperazine
2,3,4-Trimethoxybenzyl chloride (21.7 g, 0.1 mol) was dissolved in 200 mL of methanol, then 1-Boc-piperazine (22.4 g, 0.12 mol) and 2 mol/L sodium hydroxide solution 25 ml were added. Stir at 35 °C ~ 45 °C for 4 h, thenadd 100 ml of 1 mol / L hydrochloric acid solution, stir at 35 °C ~ 45 °C for 2 h, then concentrate the methanol under reduced pressure, then add 100 ml ofpurified water, with 1 mol / The sodium hydroxide solution of L was adjusted to pH 7-8, and the solid was precipitated. The solid was suction filtered, and the filter cake wasrinsed twicewith 50 ml of purified water, and then the filter cake was dried in a blast oven at 50 °C for 8 to 10 hours. 24.5 g of the target product 1-(2,3,4-trimethoxybenzyl)piperazine was obtained in a yield of 92.1%.
References:
Chenxin Pharmaceutical Co., Ltd.;Zhang Lebo;Sun Shoufei;Zhang Baikun;Li Zhongjing;Jiang Ruiling CN109666008, 2019, A Location in patent:Paragraph 0016; 0018; 0019; 0020; 0021
![4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester](/CAS/GIF/53531-01-4.gif)
53531-01-4
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$150.00/50 mg
5011-34-7
105 suppliers
$252.00/500mg
2103-57-3
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$9.00/10g
5011-34-7
105 suppliers
$252.00/500mg