An orally PI3K inhibitor: Alpelisib
Alpelisib -an orally available phosphatidylinositol 3-kinase (PI3K) inhibitor with specific activity against PI3K alpha (PI3Kα)-is being developed by Novartis for the treatment of breast cancer.
Jan 17，2024 API
Safety and Efficacy of Chloral Hydrate in Outpatient Pediatrics for Sedation
Chloral hydrate is a clinical sedative drug used for the short-term treatment of insomnia and to relieve anxiety and induce sleep prior to surgery.
Jan 17，2024 Drugs
Is 1,3-Propane sultone carcinogenic to humans?
1,3-Propane sultone (1,3-PS) is a directly alkylating, genotoxic and carcinogenic substance.
Jan 17，2024 API
Streptomycin Sulfate: Biological Activities, Efficacy in Humans and Safety
Streptomycin sulfate is an aminoglycoside antibiotic used to treat Gram-negative infections, including tuberculosis. It has potential safety concerns and is no longer a first-line option.
Jan 17，2024 API
Anastrozole: Pharmacological Properties, Therapeutic Efficacy and Tolerability
Anastrozole is a potent aromatase inhibitor with superior efficacy and favorable tolerability over tamoxifen in the treatment of early-stage breast cancer.
Jan 17，2024 API
Belumosudil: Synthesis and Description
Belumosudil is an orally active Rho-associated coiled-coil-containing protein kinase-2 (ROCK2) inhibitor recently approved for chronic graft-versus-host disease (cGVHD) after failure of two prior line
Jan 17，2024 Inhibitors
What is the connection between TBTU and HBTU?
HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis.
Jan 17，2024 Biochemical Engineering
Ponesimod: Synthesis and Description
Ponesimod was approved in 2021 for the treatment of relapsing forms of multiple sclerosis (MS). This medication is an orally administered, selective sphingosine-
Jan 17，2024 Drugs
How is Difamilast synthesised?
Difamilast is synthesised in two steps by chemical reaction using the monobenzylated protocatechuic acid ethyl ester as a raw material.
Jan 17，2024 Inhibitors
Voclosporin: Synthesis and Description
Voclosporin is a calcineurin inhibitor immunosuppressant that received its first approval by the USFDA for the treatment of active lupus nephritis, making it the first oral therapy approved in the US
Jan 17，2024 Inhibitors