Mechanism of action of Tolnaftate
Tolnaftate is an old synthetic topical thiocarbamate antifungal agent with the chemical name 2-naphthyl N-methyl-N-(3-tolyl)thlonocarbamate; the chemical structure is shown below. Clinical use of toln
Mar 30，2022 API
Pharmacodynamics and Toxicity of Tioconazole
tioconazole inhibits sterol biosynthesis by the inhibition of cytochrome P450-dependent C-14a-demethylation of lanosterol, preventing conversion to ergosterol, which results in depletion of normal fun
Mar 30，2022 API
Pharmacodynamics and Toxicity of Terconazole
Terconazole is a novel triazole ketal that was synthesized and developed by Janssen Pharmaceutica in 1983. It was the first triazole antifungal agent marketed. It has the chemical name cis-1-{p- [[2-(
Mar 30，2022 API
Pharmacodynamics of Sulconazole
Sulconazole has a broad spectrum of antifungal activity in vitro and has been shown to be an effective topical antifungal agent for the management of superficial fungal infections of the skin, particu
Mar 30，2022 API
Mechanism of action of Sertaconazole
Sertaconazole contains a benzothiophene group that both augments its antifungal activity and confers a highly lipophilic fragment that enhances the topical action and absorption of the compound into t
Mar 30，2022 API
Side effects of Oxiconazole
Oxiconazole is a substituted imidazole derivative with the chemical name 2u,4u-dichloro-2-imidazol-1-ylacetophenone(Z)-[O-(2,4-dichlorobenzyl) oxime] nitrate (C18H13Cl4N3O); the chemical structure is
Mar 30，2022 API
Mechanism of action of Neticonazole
Neticonazole is a vinyl imidazole similar to lanoconazole with the chemical name [E)-1-(2-methylthio)-1-[o-(pentyloxy)phenyl]vinyl]imidazole hydrochloride; the chemical structure is shown below. It ha
Mar 30，2022 API
Mechanism of action of Lanoconazole
Lanoconazole is a racemic imidazole antimycotic which chemically has a dithiolan ring in addition to the imidazole ring.
Mar 30，2022 API
Protective effect of 2-(trimethylsilyl)ethoxymethyl chloride
The 2-(trimethylsilyl)ethoxymethyl ether (SEM) has appeal a suitable substitute. This protecting group is stable to base and all but the harshest acidic conditions.
Mar 30，2022 API
Application and preparation of N-vinyl-2-pyrrolidone
N-Vinyl-2-pyrrolidone is an organic compound with the chemical formula C6H9ON, abbreviated as NVP.
Mar 30，2022 API