AZD3759- preclinical and clinical studies
AZD3759 is a selective EGFR inhibitor that can fully penetrate the blood-brain barrier (BBB), with equal free concentrations in the blood, cerebrospinal fluid, and brain tissue.
Dec 13，2019 Inhibitors
Neratinib- pharmacology
Neratinib is an oral pan HER inhibitor that irreversibly inhibits the tyrosine kinase activity of epidermal growth factor receptors, EGFR (or HER1), HER2, and HER4.
Dec 13，2019 Inhibitors
AP26113- Pharmacodynamics
Brigatinib (AP26113) is a tyrosine kinase inhibitor with in vitro activity against a number of kinases, including ALK, ROS1, insulin-like growth factor-1 receptor (IGF-1R), FLT-3, and also epidermal g
Dec 13，2019 Inhibitors
BIBW2992 Dimaleate - Pharmacodynamics
Afatinib dimaleate (Tovok; BIBW2992; Gilotrif) is a salt form of Afatinib. Afatinib is a second-generation, orally administered, irreversible inhibitor of the ErbB family of tyrosine kinases.
Dec 13，2019 Inhibitors
Lenvatinib - pharmacodynamics
Lenvatinib (LenvimaTM) is a multitargeted receptor kinase inhibitor that inhibits the kinase activities of vascular endothelial-derived growth factor receptors.
Dec 13，2019 Inhibitors
Antifungal performance of Terbinafine hydrochloride
Terbinafine hydrochloride is a synthetic allylamine antifungal with a broad spectrum and used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch[1].
Dec 12，2019 API
The use of pivaldehyde in organic synthesis
Pivaldehyde is an example of an aldehyde with the tertiary-butyl group (with 3 methyl groups), attached to the carbonyl (C=O) [1].
Dec 12，2019 Chemical Reagents
The application of 1-Dibenzofuranylboronic Acid in electronic devices
1-Dibenzofuranylboronic Acid is the reagent for electronic devices materials preparation. There are some synthesis routes to describe how do 1-dibenzofuranylboronic Acid works as the reagents for orga
Dec 12，2019 Pharmaceutical intermediates
The application of Sucrose octasulfate sodium salt in the digestive tract treatment
Sodium sucrose octasulfate is a chemical compound, and it has been used clinically for the prevention of gastrointestinal ulcers and was found to have cytoprotective effects.
Dec 12，2019 Saccharides
The role of 2-bromo-4-methylpropiophenone acting as intermediate for 4-MMC HCl synthesis
2-bromo-4-methylpropiophenone employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field.
Dec 12，2019 Organic Synthesis Intermediate