Biological activity of Inhibitor AC220
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively.
Oct 11，2019 InhibitorsBiological activity of PLX-4720
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations).
Oct 11，2019 InhibitorsCP-690550 as an Inhibitor
Tofacitinib citrate is a king of drugs developed by the US pharmaceutical company Pfizer for treating rheumatoid arthritis, trade name Xeljanz.
Oct 11，2019 InhibitorsBiological activity of GSK1120212
Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.
Oct 11，2019 InhibitorsBiological activity ABT-888
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays.
Oct 11，2019 Inhibitors
Preparation Method of Chlorine dioxide
Chlorine dioxide is a yellowish-green, irritating, neutral chlorine compound with the formula ClO2. It is liquefied into reddish brown liquid at 11℃, but solidified into orange red crystal at -59℃.
Oct 11，2019 Inorganic chemistry
Preparation Method of 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole
5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole is an important intermediate used in the process for preparation of Fipronil.
Oct 11，2019 Pharmaceutical intermediates
Application and side effects of Allopurinol
Allopurinol is a xanthine oxidase inhibitor that reduces the production of uric acid. Allopurinol is used to prevent gout attacks by reducing uric acid production; high levels of uric acid may cause g
Oct 11，2019 API
OxyContin:Application,Side Effects,Precautions
Oxycodone, sold under brand name Oxycontin among others, is an opioid medication used for treatment of moderate to severe pain.It is usually taken by mouth, and is available in immediate release and c
Oct 11，2019 API
The uses and side effects of Acyclovir
Acyclovir is an antiviral drug. However, it is not a cure for these infections. The viruses that cause these infections continue to live in the body even between outbreaks. Acyclovir decreases the sev
Oct 11，2019 API