Macitentan: a dual endothelin-receptor antagonist
Macitentan is an orally active, non-peptide, potent dual ERA and macitentan selectively inhibits the binding of endothelin-1 (ET-1) to ETA and ETB receptors.
Mar 24，2025 API
JAK inhibitor Upadacitinib:FDA approval,Brand name,Indications and Side effects
Upadacitinib received FDA approval on August 16, 2019, based on positive and promising results from its multinational phase III trials in subjects with moderate to severe rheumatoid arthritis.
Mar 24，2025 API
Betaine Hydrochloride: From Physiological Roles to Safety Evaluations
Betaine hydrochloride is endogenously synthesized through the metabolism of choline or exogenously consumed through dietary intake.
Mar 24，2025 Chemical Reagents
Selpercatinib (LOXO-292):Indications, Mechnaism,Clinical trials and Side effects
Selpercatinib (LOXO-292) is a highly selective RET inhibitor with activity across known oncogenic RET fusions and mutations.
Mar 21，2025 API
Fruquintinib:Indications,Trials and Side effects
Fruquintinib, as an oral tyrosine kinase inhibitor (TKI), effectively suppresses vascular endothelial growth factor/vascular endothelial growth factor receptor (VEGF/VEGFR) signaling and inhibits cell
Mar 21，2025 API
Structure, Thermostability and Multifarious Applications of Cellulases
Cellulases have been utilized in various commercial sectors including agriculture, brewing, laundry, pulp and paper and textile industry.
Mar 21，2025 Biochemical Engineering
3-Nitrophthalic Acid: A Key Compound in Organic Synthesis
3-Nitrophthalic acid can be used as starting reagent in the synthesis of modified 2-iodoxybenzoic acid derivatives.
Mar 21，2025 Chemical Reagents
Antioxidant 1076: a commercial phenolic antioxidant
Octadecyl-3,5-di-tert-butyl-4-hydroxyhydrocinnamate, well known as Antioxidant 1076, is a commercial phenolic antioxidant.
Mar 21，2025 Antioxidants
The properties and toxicity assessment of homosalate
Homosalate (HMS) is an ultraviolet (UV) filtering agent used in sunscreens and other cosmetics for skin protection purposes.
Mar 21，2025 Organic Chemistry
Pirfenidone: From Synthesis to Its Role in Treating IPF
Pirfenidone is an orally available pyridinone derivative that inhibits collagen formation and is used to treat idiopathic pulmonary fibrosis.
Mar 21，2025 API