| Identification | Back Directory | [Name]
2-Amino-5-bromoisonicotinic acid | [CAS]
1000339-23-0 | [Synonyms]
2-Amino-5-bromoisonicotinic
2-Amino-5-bromoisonicotinicaci
2-Amino-5-bromoisonicotinic acid
2-aMino-5-broMopyridin-4-carboxylic acid
2-Amino-5-bromo-4-pyridinecarboxylic acid
4-Pyridinecarboxylic acid,2-amino-5-bromo-
2-Amino-5-bromoisonicotinic acid ISO 9001：2015 REACH | [Molecular Formula]
C6H5BrN2O2 | [MDL Number]
MFCD09878357 | [MOL File]
1000339-23-0.mol | [Molecular Weight]
217.02 |
| Chemical Properties | Back Directory | [Boiling point ]
464.1±45.0 °C(Predicted) | [density ]
1.909 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
1.16±0.10(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-amino-5-bromo-4-carboxylic acid pyridine from 2-amino-5-bromoisonicotinic acid methyl ester: 2-amino-5-bromoisonicotinic acid methyl ester (10.0 g, 43.28 mmol) and lithium hydroxide (LiOH, 5.46 g, 129.8 mmol) were reacted with 2-amino-5-bromo-4-carboxylic acid methyl ester (10.0 g, 43.28 mmol) and 2-amino-5-bromoisonicotinic acid methyl ester (10.0 g, 43.28 mmol) and lithium hydroxide (LiOH, 5.46 g, 129.8 mmol) in a water (100 mL) in a solvent mixture of tetrahydrofuran (THF, 400 mL), methanol (MeOH, 200 mL), and water (100 mL), and the reaction was stirred at 70 °C for 2 h under nitrogen (N2) protection. Upon completion of the reaction, the reaction mixture was cooled to 0 °C and the pH was adjusted to 6 by dropwise addition of concentrated aqueous hydrochloric acid (HCl).Subsequently, the resulting suspension was filtered and the solid was dried under vacuum to afford pyridine 2-amino-5-bromo-4-carboxylic acid (7.8 g, 83% yield). The product was analyzed by liquid chromatography-mass spectrometry (LC-MS, ESI) and showed m/z 211 [M + H]+. | [References]
[1] Patent: WO2012/58125, 2012, A1. Location in patent: Page/Page column 145 |
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