| Identification | Back Directory | [Name]
Biotin-PEG4-Amide-C6-Azide | [CAS]
1006592-62-6 | [Synonyms]
Biotin-PEG4-Amide-C6-Azide
Biotin-PEG4-Amine-C6-Azide | [Molecular Formula]
C27H49N7O7S | [MDL Number]
MFCD30478293 | [MOL File]
1006592-62-6.mol | [Molecular Weight]
615.79 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, sealed storage, away from moisture and light | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
Biotin Azide is a biotin compound that can react with terminal alkynes via a copper-catalyzed click reaction to produce a stable triazole linkage. | [Uses]
Biotin-PEG4-Amide-C6-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG4-Amide-C6-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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