| Identification | More | [Name]
L-Histidine hydrochloride | [CAS]
1007-42-7 | [Synonyms]
L-HISTIDINE DIHYDROCHLORIDE
L-Histidine hydrochloride solution
histidine hydrochloride
Crystalline2HCl
L-Histidine hydrochloride | [EINECS(EC#)]
227-890-5 | [Molecular Formula]
C6H10ClN3O2 | [MDL Number]
MFCD00066569 | [Molecular Weight]
191.62 | [MOL File]
1007-42-7.mol |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 1789 8/PG 3
| [WGK Germany ]
3
| [F ]
3-10 |
| Hazard Information | Back Directory | [Purification Methods]
The dihydrochloride crystallises from water or aqueous EtOH and is washed with acetone, then diethyl ether. Alternatively convert it to the histidine di-(3,4-dichlorobenzenesulfonate) salt by dissolving 3,4-dichlorobenzenesulfonic acid (1.5g/10mL) in the aqueous histidine solution with warming, and then the solution is cooled in ice. The resulting crystals (m 280o dec) can be recrystallised from 5% aqueous 3,4-dichlorobenzenesulfonic acid, then dried over CaCl2 under vacuum, and washed with diethyl ether to remove Purification of Biochemicals — Amino Acids and Peptides excess reagent. The dihydrochloride can be regenerated by passing the solution through a Dowex-1 (Cl-form) ion-exchange column. The solid is obtained by evaporation of the solution on a steam bath or better in a vacuum. [Greenstein & Winitz, The Amino Acids Vol 3 p 1976 1961, Beilstein 25/16 V 366.] |
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