| Identification | More | [Name]
L-(-)-Histidinol dihydrochloride | [CAS]
1596-64-1 | [Synonyms]
H-HIS-OL 2HCL
HISTIDINOL DIHYDROCHLORIDE, L-
(L)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE
L-BETA-AMINO-1H-IMIDAZOLE-4-PROPANOL DIHYDROCHLORIDE
L-HISTIDINE DIHYDROCHLORIDE
L-HISTIDINOL 2 HCL
L-HISTIDINOL DIHYDROCHLORIDE
(S)-2-AMINO-3-(1H-IMIDAZOL-4-YL)PROPAN-1-OL DIHYDROCHLORIDE
(S)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE
S(+)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL DIHYDROCHLORIDE
beta-amino-,dihydrochloride,(s)-1h-imidazole-4-propano
beta-amino-imidazole-4-propanodihydrochloride
beta-aminoimidazole-4-propanoldihydrochloride
(S)-beta-amino-1H-imidazole-4-propanol dihydrochloride
Aminoimidazole-4-propanol dihydrochloride
((L)-2-AMINO-3-(4-IMIDAZOLYL)PROPANOL)
Imidazole-4-propanol, beta-amino, dihydrochloride.
β-Aminoimidazole-4-propanol dihydrochloride, (S)-2-Amino-3-(4-imidazolyl)propanol dihydrochloride
L-Histidinol·2hydrochloride | [EINECS(EC#)]
216-482-2 | [Molecular Formula]
C6H13Cl2N3O | [MDL Number]
MFCD00078058 | [Molecular Weight]
214.09 | [MOL File]
1596-64-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly beige crystalline powder | [Melting point ]
198-201 °C (dec.)(lit.)
| [alpha ]
-3 º (C=2, H2O 24 ºC) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Sparingly) | [form ]
Crystalline Powder | [color ]
White to slightly beige | [BRN ]
3914853 | [InChIKey]
FRCAFNBBXRWXQA-XRIGFGBMSA-N | [CAS DataBase Reference]
1596-64-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S36/37:Wear suitable protective clothing and gloves .
S22:Do not breathe dust . | [WGK Germany ]
3
| [RTECS ]
NI8260000
| [HS Code ]
29332900 |
| Hazard Information | Back Directory | [Description]
L-Histidinol is a natural amino alcohol that serves as an intermediate in the biosynthesis of the amino acid L-histidine in bacteria, archaebacteria, fungi, and plants.1,2 It is generated from its immediate precursor, L-histidinol phosphate, by a phosphatase.3,4 L-Histidinol is oxidized to L-histidinal, which in turn is oxidized to L-histidine, by a single enzyme, histidinol dehydrogenase.2 | [Chemical Properties]
white to slightly beige crystalline powder | [Uses]
A metabolite within Histidine metabolism. | [Definition]
ChEBI: L-Histidinol dihydrochloride is an aralkylamine. | [in vitro]
preliminary experiments were done to investigate the cytotoxic effect of l-histidinol on cultured eac cells. results showed that l-histidinol up to 4 mm had no cytotoxic effects on eac cells. doxorubicin alone showed concentration-dependent cytotoxic effects. l-histidinol combination with doxorubicin led to significant potentiation of doxorubicin cytotoxicity to eac cells compared to doxorubicin alone. the concentration that caused 50% growth inhibition in eac cells after 24 h incubation was about 0.2 μg/ml, whereas it was 0.1 μg/ml when l-histidinol was added to culture medium [1]. | [in vivo]
l-histidinol at 250 mg/kg for five consecutive doses before doxorubicin single injection could enhance the antitumour activity of doxorubicin in eac-bearing mice as demonstrated by a significant increase in average life span and cure rate of mice. in normal mice, l-histidinol, in the same dose regimen, could not alter the acute cardiotoxicity and lethality of doxorubicin [1]. | [References]
[1] al-shabanah oa, badary oa, al-gharably nm, al-sawaf ha. effects of l-histidinol on the antitumour activity and acute cardiotoxicity of doxorubicin in mice. pharmacol res. 1998 sep;38(3):225-30. |
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