| Identification | More | [Name]
2-AMINO-4-CHLORO-6-HYDROXY-5-NITROPYRIMIDINE | [CAS]
1007-99-4 | [Synonyms]
2-AMINO-4-CHLORO-5-NITRO-6-HYDROXYPYRIMIDINE
2-AMINO-4-CHLORO-6-HYDROXY-5-NITROPYRIMIDINE
ACHNP
AKOS 92816
2-Amino-6-chloro-5-nitropyrimidin-4-ol
2-Amino-6-chloro-5-nitropyrimidin-4(5H)-one | [Molecular Formula]
C4H3ClN4O3 | [MDL Number]
MFCD07367841 | [Molecular Weight]
190.54 | [MOL File]
1007-99-4.mol |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-amino-4-chloro-5-nitro-6-hydroxypyrimidines from 2-amino-6-chloro-4-hydroxypyrimidines: 2-amino-6-chloropyrimidin-4(3H)-one (10 g, 68.73 mmol) was dissolved in 98% sulfuric acid (46 mL) at 40 °C, keeping stirring. Subsequently, 65% nitric acid (9 g) was slowly added dropwise to the above solution. The reaction mixture was continued to be stirred at room temperature for 1 hour. Upon completion of the reaction, the solution was carefully poured into 100 g of ice to quench the reaction. The precipitate was collected by filtration and the resulting filter cake was dried in a reduced pressure oven to afford 12 g (87% yield) of the target product 2-amino-6-chloro-5-nitropyrimidin-4(3H)-one as a yellow solid. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 7.13 (1H, s), 8.59 (1H, s), 12.16 (1H, s). | [References]
[1] Chemistry (Weinheim an der Bergstrasse, Germany), 2002, vol. 8, # 1, p. 293 - 301
[2] Patent: US4939252, 1990, A
[3] Patent: WO2009/139834, 2009, A1. Location in patent: Page/Page column 93-94
[4] Journal of Heterocyclic Chemistry, 1985, vol. 22, # 4, p. 1035 - 1040
[5] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 1645 - 1660 |
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