| Identification | More | [Name]
N-Boc-3-pyrrolidinone | [CAS]
101385-93-7 | [Synonyms]
1-BOC-3-PYRROLIDINONE
1-BOC-3-PYRROLIDONE
1-N-BOC-3-PYRROLIDINONE
1-N-BOC-PYRROLIDINONE
1-PYRROLIDINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETHYLETHYL ESTER
3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
3-OXOPYRROLIDINE, N-BOC PROTECTED
BOC-3-PYRROLIDINONE
N-BOC-3-HYDROXYPYRROLIDIN-3-ONE
N-BOC-3-PYRROLIDINONE
N-BOC-PYRROLIDINE-3-ONE
N-T-BOC-3-PYRROLIDINONE
N-(TERT-BUTOXYCARBONYL)-3-PYRROLIDINONE
TERT-BUTYL 3-OXOPYRROLIDINE-1-CARBOXYLATE
3-Oxopyrrolidine, N-BOC protected 97%
N-BOC-3-PYRROLIDINONE 98%
1-BOC-3-PYRROLIDINONE/3-OXO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
1-BOC-3-PYRROLIDINONE 98%
tert-butyl 2-oxopyrrolidine-1-carboxylate
N-Boc-3-pyrolidinone | [EINECS(EC#)]
600-204-5 | [Molecular Formula]
C9H15NO3 | [MDL Number]
MFCD01631194 | [Molecular Weight]
185.22 | [MOL File]
101385-93-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
34-38 °C (lit.) | [Boiling point ]
270.9±33.0 °C(Predicted) | [density ]
1.133±0.06 g/cm3(Predicted) | [Fp ]
>230 °F
| [storage temp. ]
Store at 0-5°C | [solubility ]
Dichloromethane, Ethyl Acetate, Methanol | [form ]
Low Melting Solid | [pka]
-1.79±0.20(Predicted) | [color ]
White to yellow to orange | [Water Solubility ]
Insoluble in water. | [InChI]
InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)10-5-4-7(11)6-10/h4-6H2,1-3H3 | [InChIKey]
JSOMVCDXPUXKIC-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(=O)C1 | [CAS DataBase Reference]
101385-93-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Description]
N-Boc-3-pyrrolidinone(101385-93-7) is an organic compound insoluble in water. It is a starting material for the synthesis of spirocyclic tetrahydrofuran and is also used in studies related to the preparation of 5-membered heterocyclic secondary alcohols with carrot as a biocatalyst[1].
| [Chemical Properties]
Brown Oil | [Uses]
In the Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins 1-Boc-3-pyrrolidinone is used. | [Synthesis]
General procedure for the synthesis of 1-tert-butoxycarbonyl-3-hydroxy-pyrrolidine from 1-tert-butoxycarbonyl-3-pyrrolidinone: To a dichloromethane (20 mL) solution of oxalyl chloride (2.8 mL, 32.4 mmol) a dichloromethane (40 mL) solution of dimethylsulfoxide (DMSO, 4.6 mL, 64.8 mmol) was slowly added at -78 °C, and subsequently the reaction mixture was stirred at -15 °C for 5 min. Next, a dichloromethane (60 mL) solution of N-Boc-3-pyrrolidinol (4.04 g, 21.6 mmol) was added at -78°C and stirring was continued for 2 hours at this temperature. Subsequently, triethylamine (15 mL, 108 mmol) was added to the reaction mixture and stirred at -78 °C for 1 hour. After that, the reaction mixture was slowly warmed to room temperature and stirring was continued for 2 hours at room temperature. After completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and diluted with ethyl acetate. The organic layer was washed sequentially with saturated sodium bicarbonate solution and saturated saline. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the crude product 1-tert-butoxycarbonyl-3-pyrrolidinone (4 g, 100% yield), which could be used for subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.79-3.75 (m, 4H), 2.58 (t, J = 8.0 Hz, 2H), 1.47 (s, 9H). | [References]
[1] NAIRA VIEIRA MACHADO á. O. Enantioselective reduction of heterocyclic ketones with low level of asymmetry using carrots[J]. Biocatalysis and Biotransformation, 2021. DOI:10.1080/10242422.2021.1879795. |
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