| Identification | More | [Name]
PHENYLMERCURIC BORATE | [CAS]
102-98-7 | [Synonyms]
CORUBEX(R)
[DIHYDROGEN BORATO]PHENYL MERCURY
FAMOSEPT(R)
MERFEN(R)
PHENYLMERCURIBORATE
PHENYLMERCURIC BORATE
PHENYLMERCURY BORATE
(dihydrogenborato)phenyl-mercur
(orthoborato(3-)-o)phenyl-mercurate(2-dihydrogen
boricacid,phenylmercuryderiv.
dihydrogen[orthoborato(3-)-o]phenylmercurate(2-
dihydrogen[orthoborato(3-)-o]phenylmercurate(2-)
exomycolgel
famosept
fenosept
formasept
merfen
merphen
metasolbt
phenylmercurydihydrogenborate | [EINECS(EC#)]
203-068-1 | [Molecular Formula]
C6H7BHgO3 | [MDL Number]
MFCD00019938 | [Molecular Weight]
338.52 | [MOL File]
102-98-7.mol |
| Safety Data | Back Directory | [Risk Statements ]
R28:Very Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2026 | [HazardClass ]
6.1(a) | [PackingGroup ]
II |
| Hazard Information | Back Directory | [Chemical Properties]
Phenylmercuric borate occurs as colorless, shiny flakes or as a white
or slightly yellow, odorless, crystalline powder. | [Uses]
Phenylomercuric borate is primarily used as an antibacterial preservative in topical pharmaceutical preparations. For example, a composition for treating ocular fungal and bacterial infections can be prepared by using at least one of the following mercury-based preservatives with dual antifungal and antibacterial effects: thimerosal, phenylmercuric nitrate, phenylmercuric nitrate base, phenylmercuric acetate, phenylmercuric borate, tert-butylmercuric acid, mercuric cyanide, sodium benzylsulfonylmercuric acid, and salts and derivatives of any of these compounds as the main active ingredient. This composition, along with excipients composed of antioxidants, pH adjusters, and osmotic pressure adjusters, and water—a carrier for dissolving the aforementioned mercury-based preservatives and excipients—to form the composition for treating ocular fungal and bacterial infections of this invention. This composition can be used in various ophthalmic dosage forms and is highly effective in treating fungal keratitis, thus providing patients and doctors with a new, safe, efficient, inexpensive, and convenient ophthalmic composition with dual antifungal and antibacterial effects. | [Production Methods]
Phenylmercuric borate may be prepared by heating mercuric borate
with benzene or by evaporating to dryness, under vacuum, an
alcoholic solution containing equimolar proportions of phenylmercuric
hydroxide and boric acid. | [Pharmaceutical Applications]
Phenylmercuric borate is used as an alternative antimicrobial
preservative to phenylmercuric acetate or phenylmercuric nitrate. It
is more soluble than phenylmercuric nitrate and has also been
reported to be less irritant than either phenylmercuric acetate or
phenylmercuric nitrate. | [Safety]
Phenylmercuric borate is mainly used as an antimicrobial preservative
in topical pharmaceutical formulations. A number of
adverse reactions to mercury-containing preservatives have been
reported; see Phenylmercuric Nitrate.
Although phenylmercuric borate is an irritant, it has been
reported to be less so than either phenylmercuric acetate or phenylmercuric nitrate.(1) There is, however, some cross-sensitization
potential with other mercurial preservatives.
Systemic absorption has been reported following regular use of a
hand disinfectant soap containing 0.04% phenylmercuric borate,
resulting in an increase in the estimated total daily body load of
mercury from 30–100 mg per 24 hours. | [storage]
As for other phenylmercuric salts; see Phenylmercuric Nitrate.
Solutions may be sterilized by autoclaving.
Phenylmercuric borate should be stored in a well-closed
container, protected from light, in a cool, dry place. | [Incompatibilities]
Incompatible with: halides; anionic emulsifying agents and
suspending agents; tragacanth; starch; talc; sodium metabisulfite;
sodium thiosulfate; disodium edetate; silicates; aluminum and other
metals; amino acids; ammonia and ammonium salts; sulfur
compounds; rubber; and some plastics.
Phenylmercuric acetate is reported to be incompatible with
cefuroxime and ceftazidime. | [Regulatory Status]
Included in nonparenteral medicines licensed in Europe. Included in
the Canadian List of Acceptable Non-medicinal Ingredients
(ophthalmic, nasal and otic preparations up to 0.004%; there
must be no other suitable alternative preservative).
In Europe, use is limited to eye makeup and eye makeup remover
at not more than 0.007% mercury alone or in combination with
other permitted mercurial substances.In France, a maximum
concentration of up to 0.01% is permitted for use in pharmaceutical
formulations. Prohibited from use in cosmetic products in Canada.
Prohibited in antimicrobial diaper rash drug products in the USA.
Limited use in Japan (see Phenylmercuric Nitrate). |
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