| Identification | Back Directory | [Name]
HYDROXYZINE PAMOATE | [CAS]
10246-75-0 | [Synonyms]
Atarax P
Equipose
Masmoran
Paxisitil
Hatanazin
Chebi:31680
Vistaril pamoate
Hydroxidine pamoate
HYDROXYZINE PAMOATE
Hydroxyzyne pamoate
hydroxyzine embonate
HYDROXYZINEPAMOATE,USP
HYDROXYZINE PAMOATE SALT
2-Naphthoic acid, 4,4'-methylenebis[3-hydroxy-, hydroxyzine salt (6CI)
1-(p-Chloro-α-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine, pamoate
Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]-, 4,4'-methylenebis[3-hydroxy-2-naphthoate] (1:1) (salt) (8CI)
1-[(4-Chlorophenyl)(phenyl)methyl]-4-[2-(2-hydroxyethoxy)ethyl]piperazinediium 4,4'-methylenebis(3-hydroxynaphthalene-2-carboxylate)
2-Naphthoic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol (1:1) (8CI)
Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (1:1) (9CI)
2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol (1:1) | [EINECS(EC#)]
233-582-1 | [Molecular Formula]
C44H43ClN2O8 | [MDL Number]
MFCD00058051 | [MOL File]
10246-75-0.mol | [Molecular Weight]
763.27 |
| Chemical Properties | Back Directory | [Melting point ]
>155°C (dec.) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [color ]
Yellow | [Major Application]
pharmaceutical | [InChIKey]
ASDOKGIIKXGMNB-UHFFFAOYSA-N | [SMILES]
ClC1=CC=C(C=C1)C(N2CCN(CCOCCO)CC2)C3=CC=CC=C3.O=C(O)C4=C(O)C(CC5=C(C=CC=C6)C6=CC(C(O)=O)=C5O)=C7C=CC=CC7=C4 |
| Hazard Information | Back Directory | [Uses]
anxiolytic, antihistaminic | [in vivo]
Hydroxyzine pamoate can be administered intravenously and orally[2].
Hydroxyzine pamoate metabolite deschlorocycline induces congenital malformations[4].
Example of configuring an oral suspension of Hydroxyzine pamoate 5 mg/mL: Hydroxyzine pamoate 850 mg, Xanthan gum 1 g, Propylene glycol 5 mL, Sorbic acid 200 mg, Sorbitol solution 20 mL, Flavor q.s., Syrup q.s. to 100 mL[5]. | Animal Model: | Mature female pregnant rats weighing 240 g[4] | | Dosage: | 100, 200 mg/kg | | Administration: | | | Result: | Showed 100 mg/kg produced 25.7% and 42.9% deformed pups per kilogram of body weight; 200 mg/kg produced 100% deformed pups per kilogram of body weight. |
| Animal Model: | Dog received IV hydroxyzine dihydrochloride[2][3] | | Dosage: | 2 mg/kg; daily; one day | | Administration: | Intravenous injection (i.v.); Oral gavage (p.o.) | | Result: | Showed that there was no significant difference at the 5% level in GWS (erythema×firmness×average diameter) between the two dosing methods. |
| [IC 50]
H1 Receptor | [storage]
Store at -20°C,sealed storage, away from moisture |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
36 | [WGK Germany ]
3
| [HS Code ]
2933595960 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|