| Identification | More | [Name]
1-Hydroxyethylethoxypiperazine | [CAS]
13349-82-1 | [Synonyms]
1-[2-(2-HYDROXYETHOXY)ETHYL]PIPERAZINE
1-[2-(2-HYDROXYETHOXYL)-ETHYL] PIPERAZINE
1-HYDROXYETHYLETHOXYPIPERAZINE
2-[2-(1-PIPERAZINE)ETHOXY]ETHANOL
2-[2-(1-PIPERAZINYL)ETHOXY]ETHANOL
2-(2-PIPERAZIN-1-YL-ETHOXY)-ETHANOL
HEP
N-HYDROXYETHOXYETHYL PIPERAZINE
1-[2-(2-HYDROXYETHOXY)ETHYL] PIPERAZINE (HEEP)
1-Hydroxyethoxyethylpiperazine
2-[2-(1-piperazidine)ethoxy]ethanol
Ethanol, 2-[2-(1-piperazinyl)ethoxy]-(6CI,8CI,9CI)
Quetiapine intermediate
2-[2-(1-Piperazidine)ethoxy]et
1-[2-(2-hydroxyethoxy)ethyl]piperazine (intermediate of quetiapine fumarate)
N-[2-(2-HYDROXYETHOXY)ETHYL]PIPERAZINE
1-[2-(2-HYDROXYETHOXY)ETHYL]PIPERAZINE 99%
2-(2-Piperazinoethoxy)ethanol | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C8H18N2O2 | [MDL Number]
MFCD00074931 | [Molecular Weight]
174.24 | [MOL File]
13349-82-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow-Brown Oil | [Boiling point ]
112-114 °C0.25 mm Hg(lit.)
| [density ]
1.061 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.497(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
14.41±0.10(Predicted) | [color ]
Clear colorless to yellow-brownish | [Specific Gravity]
1.061 | [Usage]
Quetiapine intermediate | [InChI]
InChI=1S/C8H18N2O2/c11-6-8-12-7-5-10-3-1-9-2-4-10/h9,11H,1-8H2 | [InChIKey]
FLNQAPQQAZVRDA-UHFFFAOYSA-N | [SMILES]
C(O)COCCN1CCNCC1 | [CAS DataBase Reference]
13349-82-1(CAS DataBase Reference) | [NIST Chemistry Reference]
1-(2-(2-Hydroxyethoxy)ethyl)piperazine(13349-82-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow-Brown Oil | [Uses]
Quetiapine intermediate | [Definition]
ChEBI: 1-(2-(2-Hydroxyethoxy)ethyl)piperazine is a N-alkylpiperazine. | [Synthesis]
The general procedure for the synthesis of 1-[2-(2-hydroxyethoxy)ethyl]piperazine from the compound (CAS:166388-52-9) was as follows: 54.2 g of compound 3 was dissolved in 300 mL of dichloromethane, followed by the addition of 26 g of trifluoroacetic acid. The reaction mixture was stirred at room temperature for 2 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. After completion of the reaction, 1 N NaOH aqueous solution was added and stirring was continued for 30 minutes. The reaction mixture was left to partition and the organic phase was separated. The organic phase was dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 32.6 g of a colorless liquid product, i.e., 1-[2-(2-hydroxyethoxy)ethyl]piperazine. The yield was 95%. | [References]
[1] Patent: CN107663183, 2018, A. Location in patent: Paragraph 0022; 0023; 0024 |
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