| Identification | Back Directory | [Name]
LB-100 | [CAS]
1026680-07-8 | [Synonyms]
LB-100
CS-1762
LB-100, >95%
LB-100, 1026680-07-8
3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
3-(1-methylpiperazine-4-carbonyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid
methyl 2,5-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-3-carboxylate LB-100
LB-100 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID | [Molecular Formula]
C13H20N2O4 | [MDL Number]
MFCD28167839 | [MOL File]
1026680-07-8.mol | [Molecular Weight]
268.309 |
| Chemical Properties | Back Directory | [Melting point ]
>214°C (dec.) | [storage temp. ]
Amber Vial, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated) | [form ]
Solid | [color ]
White |
| Hazard Information | Back Directory | [Uses]
LB-100 is a small molecule inhibitor of protein phosphatase 2A with potent chemo- and radio-sensitizing potential in variety of cancer types including pancreatic cancer and colorectal cancer of human and animal model. | [Biological Activity]
lb-100 is an inhibitor of protein phosphatase 2a (pp2a) with anticancer activity, with ic50 of 0.85 μm and 3.87 μm in bxpc-3 and panc-1 cells, respectively[1].in bxpc-3, panc-1, and sw1990 cells, lb-100 treatment reduced pp2a activity by 30-50%. lb-100 increases the intracellular doxorubicin concentration (about 2.5 times that of the control group) and makes tumor cells more sensitive to the cytotoxicity of doxorubicin[1].in a panc-1 mouse xenograft model, lb-100 (2 mg / kg, intraperitoneal injection) improves the efficacy of the chemotherapy drug doxorubicin. lb-100 increases tumor microvessel density and blood flow velocity on the tumor surface, and decreases tumor volume[1].[1]. bai x, zhi x, zhang q, et al. inhibition of protein phosphatase 2a sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via hif-1α-vegf mediated angiogenesis. cancer lett, 2014, 355(2): 281-287. | [storage]
Store at -20°C |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
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