| Identification | Back Directory | [Name]
Moracin P | [CAS]
102841-46-3 | [Synonyms]
Moracin P
(9R)-moracin P
5-(6-hydroxy-7,7-dimethyl-3a,4,5,6-tetrahydrofuro[3,2-g]chromen-2-yl)benzene-1,3-diol
5-[(6R)-6,7-Dihydro-6-hydroxy-7,7-dimethyl-5H-furo[3,2-g][1]benzopyran-2-yl]-1,3-benzenediol
1,3-Benzenediol, 5-[(6R)-6,7-dihydro-6-hydroxy-7,7-dimethyl-5H-furo[3,2-g][1]benzopyran-2-yl]- | [Molecular Formula]
C19H18O5 | [MDL Number]
MFCD21333739 | [MOL File]
102841-46-3.mol | [Molecular Weight]
326.34 |
| Chemical Properties | Back Directory | [Boiling point ]
560.6±50.0 °C(Predicted) | [density ]
1.349±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
9.10±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects[1][2][3]. | [target]
ROS | HIF | NO | [References]
[1] Hak Ju Lee, et al. Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (Moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells. Arch Pharm Res. 2011 Aug;34(8):1373-80. DOI:10.1007/s12272-011-0818-4
[2] Yan Xia, et al. HIF-1α inhibitors: synthesis and biological evaluation of novel moracin O and P analogues. Eur J Med Chem. 2011 Jun;46(6):2386-96. DOI:10.1016/j.ejmech.2011.03.022
[3] Besse Hardianti, et al. Anti-inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF?κB pathway. Mol Med Rep. 2020 Dec;22(6):5385-5391. DOI:10.3892/mmr.2020.11615 |
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