ChemicalBook--->CAS DataBase List--->103-69-5

103-69-5

103-69-5 Structure

103-69-5 Structure
IdentificationMore
[Name]

N-Ethylaniline
[CAS]

103-69-5
[Synonyms]

ANILINOETHANE
ethylphenylamine
N-ETHYLAMINOBENZENE
N-ETHYLANILINE
N-ETHYL-N-PHENYLAMINE
N-ETHYLPHENYLAMINE
N-MONOETHYLANILINE
Aethylanilin
Aniline, N-ethyl-
Ethylaniline
N-EthylaniIine
n-ethyl-anilin
n-ethyl-benzenamin
N-Ethylbenzenamine
N-ethyl-Benzenamine
n-ethylbenzenamino
n-ethylbenzeneamino
Monoethylaniline
N-EthylamineForSynthesis
N-Ethylaniline>99%
[EINECS(EC#)]

203-135-5
[Molecular Formula]

C8H11N
[MDL Number]

MFCD00009025
[Molecular Weight]

121.18
[MOL File]

103-69-5.mol
Chemical PropertiesBack Directory
[Appearance]

N-Ethylaniline is yellow-brown oil with a weak fishy odor.
[Melting point ]

-63 °C
[mp ]

-63 °C
[Boiling point ]

205 °C(lit.)
[bp ]

205 °C(lit.)
[density ]

0.963 g/mL at 25 °C(lit.)
[vapor density ]

4.2 (vs air)
[vapor pressure ]

0.2 mm Hg ( 25 °C)
[refractive index ]

n20/D 1.554(lit.)
[Fp ]

185 °F
[storage temp. ]

Store below +30°C.
[solubility ]

2.7g/l
[pka]

5.12(at 24℃)
[form ]

Liquid
[color ]

Clear light yellow to light brown
[Stability:]

Stable, but decomposes upon prolonged exposure to air or light. Combustible. Incompatible with strong oxidizing agents. May react violently with nitric acid.
[PH]

11 (2.7g/l, H2O, 20℃)
[explosive limit]

1.8-10.0%(V)
[Water Solubility ]

50 g/L (20 ºC)
[Sensitive ]

Air & Light Sensitive
[Merck ]

14,3764
[BRN ]

507468
[Uses]

Organic synthesis.
[CAS DataBase Reference]

103-69-5(CAS DataBase Reference)
[NIST Chemistry Reference]

Benzenamine, N-ethyl-(103-69-5)
[EPA Substance Registry System]

103-69-5(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
[Safety Statements ]

S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S37:Wear suitable gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 2272 6.1/PG 3
[WGK Germany ]

1
[RTECS ]

BX9780000
[F ]

8
[Hazard Note ]

Toxic
[TSCA ]

Yes
[HazardClass ]

6.1
[PackingGroup ]

III
[HS Code ]

29214200
[Safety Profile]

Poison by ingestion and intraperitoneal routes. Moderately toxic by an unspecified route. Mddly toxic by skin contact. An allergen. Flammable when exposed to heat or flame; can react with oxidizing materials. To fight fire, use dry chemical, CO2, foam. Hypergolic reaction with red fuming nitric acid. When heated to decomposition or on contact with acid or acid fumes it emits highly toxic fumes of aniline and NOx.
[Hazardous Substances Data]

103-69-5(Hazardous Substances Data)
[Toxicity]

LD50 in rats (g/kg): 0.18 i.p., 0.28 orally, 4.7 s.c. (Sziza, Podhragyai)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethanol-->Aniline-->Tosyl chloride-->2-Ethylaniline
[Preparation Products]

Reactive Blue BRF-->Acid Violet 17-->Zinc ethylphenyl dithiocarbamate-->4-(2-(N-PHENYL-N-ETHYLAMINO)ETHOXY)-3,5-DICHLOROBENZENAMINE-->Reactive Red ME-2G-->[2-[[4-[(2-cyano-4-nitrophenyl)azo]phenyl]ethylamino]ethyl]trimethylammonium methyl sulphate-->[2-[ethyl[4-[(4-nitrophenyl)azo]phenyl]amino]ethyl]trimethylammonium chloride-->[2-[[4-[(2-chloro-4-nitrophenyl)azo]phenyl]ethylamino]ethyl]trimethylammonium-->Disperse Scarlet SE-R-->Benzenamine, N-ethyl-4-nitro-N-nitroso--->Disperse Violet 77-->Disperse Blue 257-->N-Ethylcyclohexylamine-->N-NITROSO-N-ETHYLANILINE-->N-Chloroethyl-N-ethylaniline-->Paquinimod-->Reactive Red 252-->trisodium 5-[[4-chloro-6-(ethylphenylamino)-1,3,5-triazin-2-yl]amino]-4-hydroxy-3-[(2-sulphonatophenyl)azo]naphthalene-2,7-disulphonate
Hazard InformationBack Directory
[General Description]

A dark liquid with an aromatic odor. Insoluble in water. Density 0.963 g/cm3. Toxic by skin absorption and inhalation of vapors. Evolves toxic fumes during combustion. Flash point 185°F.
[Reactivity Profile]

N-ETHYLANILINE(103-69-5) may react violently with nitric acid. May react with strong oxidizing agents. . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
[Air & Water Reactions]

Unstable to prolonged exposure to air and/or light. Insoluble in water.
[Hazard]

Toxic by ingestion, inhalation, and skin absorption.
[Health Hazard]

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
[Potential Exposure]

This material is used as an intermediate in dyes, pharmaceuticals and explosives; in organic synthesis.
[Fire Hazard]

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
[First aid]

Eye Contact: Immediately remove any contact lenses and flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention if any symptoms are present. Skin Contact: Quickly remove contaminated clothing. Immediately wash area with large amounts of soap, promptly seek medical attention Breathing: Remove the person from exposure. Begin (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility.
[Shipping]

UN2272 N-Ethylaniline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
[Incompatibilities]

May form explosive mixture with air. Decomposes on contact with light or air. Reacts with many materials. Neutralizes acids in exothermic reactions to form salts plus water. Flammable gaseous hydrogen may be generated in combination with strong reducing agents such as hydrides, nitrides, alkali metals, and sulfides. Contact with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials; strong acids, such as nitric acid, can cause fire; explosions with formation of toxic vapors of aniline and oxides of nitrogen; strong bases, isocyanates, halogenated organics, phenols (acidic), epoxides, anhydrides, and acid halides
[Chemical Properties]

N-Ethylaniline is yellow-brown oil with a weak fishy odor.
[Chemical Properties]

yellow liquid
[Occurrence]

Polyethylene bottles used in intravenous solutions have been reported to be contaminated with N-ethylaniline from rubber parts of the closure (Ulsaker and Teien 1979). It has been reported that rubber containing N,N,-dithiodimorpholine accelerator of vulcanization can release N-ethylaniline into an aqueous media (Stankevich and Shurupova 1976). This compound has also been reported as a contaminant of cigarette smoke at a level of 55.8 ng per one U.S. 85 mm cigarette (Patrianakos and Hoffmann 1979).
[Production Methods]

Manufacture of N-ethylaniline is based on the reaction of aniline with alkyl halide or by heating aniline with ethyl alcohol under acidic conditions followed by purification (Windholz et al 1983).
[Synthesis Reference(s)]

Journal of the American Chemical Society, 78, p. 4778, 1956 DOI: 10.1021/ja01599a063
The Journal of Organic Chemistry, 21, p. 988, 1956
Tetrahedron Letters, 25, p. 1635, 1984 DOI: 10.1016/S0040-4039(01)81131-X
[Industrial uses]

N-Ethylaniline is used as an explosives stabilizer and as an intermediate in the manufacturing of dyes and pharmaceuticals (Northcott 1978).
[Metabolism]

The metabolism of N-ethylaniline has been studied more as a tool to understanding microsomal drug metabolizing activity than as the central item of inquiry. However, the following have been clearly defined as metabolic products of N-ethylaniline: phenylhydroxylamine, N-hydroxyl, N-ethylaniline; N-ethyl-p-aminophenol; and aniline (Appel et al 1965; Heinze 1970; Hlavica 1970; Hlavica and Kiese 1969; Kampffmeyer and Kiese 1965; Kroeber et al 1970; Lange 1967 and Lange 1968). Nonmicrosomal metabolism has not been reported. Species shown capable of metabolism include rabbit, mouse, rat, dog, pig, and guinea pig with the proportions of the various metabolites often species dependent. Compounds similar to N-ethylaniline such as N-methyl-N-ethylaniline can form N-ethylaniline via demethylation (Gorrod et al 1975a,b).
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

N-ethylaniline(103-69-5).msds
Spectrum DetailBack Directory
[Spectrum Detail]

N-Ethylaniline(103-69-5)MS
N-Ethylaniline(103-69-5)1HNMR
N-Ethylaniline(103-69-5)13CNMR
N-Ethylaniline(103-69-5)IR1
N-Ethylaniline(103-69-5)IR2
N-Ethylaniline(103-69-5)ESR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

N-Ethylaniline, 98%(103-69-5)
[Alfa Aesar]

N-Ethylaniline, 97%(103-69-5)
[Sigma Aldrich]

103-69-5(sigmaaldrich)
[TCI AMERICA]

N-Ethylaniline,>99.0%(GC)(103-69-5)
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