| Identification | More | [Name]
2-BROMO-4-TERT-BUTYLANILINE | [CAS]
103273-01-4 | [Synonyms]
BUTTPARK 83\07-24
2-BROMO-4-TERT-BUTYLANILINE
2-BROMO-4-TERT-BUTYL-PHENYLAMINE
1-Amino-2-bromo-4-(tert-butyl)benzene
Benzenamine,2-bromo-4-(1,1-dimethylethyl)- | [Molecular Formula]
C10H14BrN | [MDL Number]
MFCD00052693 | [Molecular Weight]
228.13 | [MOL File]
103273-01-4.mol |
| Chemical Properties | Back Directory | [Boiling point ]
265°C(lit.) | [density ]
1.306±0.06 g/cm3(Predicted) | [refractive index ]
1.5680 to 1.5720 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
clear liquid | [pka]
2.86±0.10(Predicted) | [color ]
Colorless to Red to Green | [InChI]
InChI=1S/C10H14BrN/c1-10(2,3)7-4-5-9(12)8(11)6-7/h4-6H,12H2,1-3H3 | [InChIKey]
OLKYFBNIFKQRIZ-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(C(C)(C)C)C=C1Br | [CAS DataBase Reference]
103273-01-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
2921490090 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow liquid | [Uses]
2-Bromo-4-tert-butylaniline is commonly employed in organic synthesis for the production of various compounds, including 8-Bromo-6-tert-butylquinoline. It can also be used in the production of dyes and pigments, pharmaceutical intermediates, and agrochemicals. | [Preparation]
4-(tert-butyl)aniline (50.0 g, 335.1 mmol), dissolved in 1.1 L of acetonitrile, was added to a flask. After cooling the mixture to 0 ℃, NBS (59.6 g, 335.1 mmol) was added and the temperature was raised to room temperature for 12 hours. After that, water (800 mL) was added, extracted with dichloromethane, and the solvent was concentrated under reduced pressure. The dichloromethane (700 mL) was added to the mixture, washed with 400 mL of 2N NaOH, filtered through a silica pad, and the solvent was concentrated under reduced pressure to obtain 2-Bromo-4-tert-butylaniline. | [Hazard]
H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (33.33%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (33.33%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
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