| Identification | More | [Name]
Octyl gallate | [CAS]
1034-01-1 | [Synonyms]
GALLIC ACID N-OCTYL ESTER
GALLIC ACID OCTYL ESTER
N-OCTYL GALLATE
OCTYL 3,4,5-TRIHYDROXYBENZOATE
OCTYL GALLATE
3,4,5-trihydroxy-benzoicacioctylester
n-octylesterof3,4,5-trihydroxybenzoicacid
oktylesterkyselinygallove
Gallic Acid Octyl Eester
Benzoic acid, 3,4,5-trihydroxy-, octyl ester
OCTYL GALLATE(OCTYL 3,4,5-TRIHYDROXYBENZOATE)
OCTYLGALLATE(RG)
n-Octyl gallate, 98+%
Progallin O
3,4,5-Trihydroxybenzoic acid octyl ester
Gallic acid octyl
Stabilizer GA-8 | [EINECS(EC#)]
213-853-0 | [Molecular Formula]
C15H22O5 | [MDL Number]
MFCD00002197 | [Molecular Weight]
282.33 | [MOL File]
1034-01-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
101-104 °C(lit.)
| [Boiling point ]
262.5°C (estimate) | [density ]
1.0984 (rough estimate) | [refractive index ]
1.6200 (estimate) | [storage temp. ]
0-6°C | [solubility ]
soluble2.5%, clear, colorless (AcOH (MEOH)) | [form ]
neat | [pka]
7.94±0.25(Predicted) | [color ]
White to Off-White | [Water Solubility ]
20mg/L(29.99 ºC) | [BRN ]
2132305 | [Contact allergens]
Octyl gallate, a gallate ester (E 311), is an antioxidant
added to food and cosmetics to prevent oxidation of unsaturated
fatty acids. Cases were sparsely reported in food
industry or from lipsticks. Patch tests are frequently irritant. | [LogP]
3.660 | [Uses]
Used in treatment of alcohol dependence. | [CAS DataBase Reference]
1034-01-1(CAS DataBase Reference) | [EPA Substance Registry System]
1034-01-1(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Definition]
ChEBI: A gallate ester obtained by condensation of the carboxy group of gallic acid with the hydroxy group of octanol. | [General Description]
Octyl gallate is an ester of gallic acid which is generally used as an antioxidant in food and pharmaceutical industries. It can act against the oxidative damage caused by reactive oxygen species (ROS) in the form of hydroxyl radicals or hydrogen peroxides, and reactive sulfur species (RSS) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R43:May cause sensitization by skin contact. | [Safety Statements ]
S24:Avoid contact with skin .
S37:Wear suitable gloves . | [WGK Germany ]
1
| [RTECS ]
LW8225000
| [TSCA ]
Yes | [HS Code ]
29182900 | [Safety Profile]
A poison by
intraperitoneal route. Moderately toxic by
ingestion. When heated to decomposition it
emits acrid smoke and irritating fumes. | [Toxicity]
LD50 orally in Rabbit: 1960 mg/kg |
| Questions And Answer | Back Directory | [Description]
Octyl gallate is the ester formed by 1-octanol and gallic acid. It can be used as an antioxidant and preservative to be supplemented to the food. It has been demonstrated to be an effective fungicide being capable of inhibiting the growth of S. cerevisiae and Z. bailii as it can inhibit the fluidity of the cell membrane through acting as a nonionic surface-active agent. It is also capable of killing both DNA and RNA viruses with a relatively moderate cytotoxicity. For example, it has the potential to treat influenza. Octyl gallate also has certain bactericidal activity, being capable of treating the infections associated with enterococci.
| [References]
[1]Ken-Ichi, Fujita, and K. Isao. "Antifungal activity of octyl gallate. " International Journal of Food Microbiology 79.3(2002):1
[2]Gutiérrez-Fernández, J, et al. "Antimicrobial activity of binary combinations of natural and synthetic phenolic antioxidants against Enterococcus faecalis. " Journal of Dairy Science 96.8(2013):4912-20.93.
[3] Yamasaki, H, et al. "Antiviral effect of octyl gallate against influenza and other RNA viruses. " International Journal of Molecular Medicine 19.4(2007): 685-688.
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