| Identification | More | [Name]
Methyl gallate | [CAS]
99-24-1 | [Synonyms]
3,4,5-TRIHYDROXYBENZOIC ACID METHYL ESTER
AKOS 217-13
GALLIC ACID METHYL ESTER
GALLICIN
METHYL 3,4,5-TRIHYDROXYBENZOATE
METHYL GALLATE
RARECHEM AL BF 0070
3,4,5-trihydroxy-benzoicacimethylester
3,4,5-trihydroxybenzoic acid methyl ester (intermediate of bifendate)
METHYL GALLATE(METHYL 3,4,5-TRIHYDROXYBENZOATE )
METHYLGALLATE(RG)
2-diazo-1-naphthol-5-sulfonic acid, ester with novolac
METHYGALLATE
3,4,5-trihydroxy-benzoic acidd methyl ester
METHYL 3,4,5-TRIHYDROXYBENZOATE/METHYL GALLATE
Gallic acid methyl ester, Methyl 3,4,5-trihydroxybenzoate
Benzoic acid, 3,4,5-trihydroxy, methyl ester
Methyl 3,4,5-trihydroxybenzoate, 99 %
(3aS,10E)-3aβ,4,5,6,7,8,9,11aα-Octahydro-7α-hydroxy-6-methylene-3β,10-dimethylcyclodeca[b]furan-2(3H)-one | [EINECS(EC#)]
202-741-7 | [Molecular Formula]
C8H8O5 | [MDL Number]
MFCD00002194 | [Molecular Weight]
184.15 | [MOL File]
99-24-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly beige crystalline powder | [Melting point ]
201-204 °C
| [Boiling point ]
278.08°C (rough estimate) | [density ]
1.3840 (rough estimate) | [refractive index ]
1.5690 (estimate) | [storage temp. ]
2-8°C | [solubility ]
ethanol: 50 mg/mL, clear
| [form ]
Crystalline Powder | [pka]
8.04±0.23(Predicted) | [color ]
White to slightly beige | [Water Solubility ]
SOLUBLE IN HOT WATER | [Merck ]
14,4345 | [BRN ]
2113180 | [InChI]
1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3 | [Contact allergens]
This ester of gallic acid is used as an antioxidant agent. A case was reported by using a reprography paper. | [InChIKey]
FBSFWRHWHYMIOG-UHFFFAOYSA-N | [SMILES]
COC(=O)c1cc(O)c(O)c(O)c1 | [LogP]
0.860 | [CAS DataBase Reference]
99-24-1(CAS DataBase Reference) | [EPA Substance Registry System]
99-24-1(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly beige crystalline powder | [Uses]
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. | [Description]
Methyl gallate is a phenolic compound found in Terminalia myriocarpa and Geranium niveum. It is also found in wine.
It is the methyl ester of gallic acid. | [Definition]
ChEBI:Methyl 3,4,5-trihydroxybenzoate is a gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties. It has a role as a plant metabolite, an anti-inflammatory agent and an antioxidant. | [Biological Activity]
A large number of cell and animal experiments have shown that MG has good therapeutic effects, such as anti-tumor, anti-inflammatory, anti-oxidation, anti-microbial, anti-malarial and so on[5]. | [Source]
Methyl gallate is widely found in natural plants, such as Juglans mandshurica, Galla chinensis, Paeonia anomala, Phyllanthus emblica, Mangifera indica, Plicosepalus acacia, Carica papaya Linn, and Maple (Genus Acer)[5]. | [storage]
Store at -20°C | [Purification Methods]
Methyl gallate [99-24-1] M 184.2, m 202o. Crystallise the gallate ester from MeOH. [Beilstein 10 IV 1998.] | [References]
[1] MISO JEON Yong S K Naimur Rahman. Wnt/β-catenin signaling plays a distinct role in methyl gallate–mediated inhibition of adipogenesis[J]. Biochemical and biophysical research communications, 2016, 479 1: Pages 22-27. DOI: 10.1016/j.bbrc.2016.08.178
[2] PRASANTA K. BAG . In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae[J]. Microbial pathogenesis, 2019, 128: Pages 41-46. DOI: 10.1016/j.micpath.2018.12.037
[3] HEEKYUNG LEE. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.[J]. Journal of immunology, 2010: 6698-6705. DOI: 10.4049/jimmunol.1001373
[4] LUANA BARBOSA CORREA. Anti-inflammatory Effect of Methyl Gallate on Experimental Arthritis: Inhibition of Neutrophil Recruitment, Production of Inflammatory Mediators, and Activation of Macrophages[J]. Journal of Natural Products , 2016, 79 6: 1554-1566. DOI: 10.1021/acs.jnatprod.5b01115 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P301+P312+P330-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R43:May cause sensitization by skin contact. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [RTECS ]
LW8000000
| [TSCA ]
Yes | [HS Code ]
29182900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
|