| Identification | More | [Name]
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride | [CAS]
104075-48-1 | [Synonyms]
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride
Atipamezole HCL
4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride
4-(2-Ethyl-2-indanyl)imidazole hydrochloride
Atipamezole hydrochloride | [EINECS(EC#)]
105-700-9 | [Molecular Formula]
C14H16N2.HCl | [MDL Number]
MFCD06407819 | [Molecular Weight]
248.75 | [MOL File]
104075-48-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
211-215° | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Merck ]
14,861 | [InChI]
InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H | [InChIKey]
PCCVCJAQMHDWJY-UHFFFAOYSA-N | [SMILES]
C1(CC)(CC2=C(C=CC=C2)C1)C1=CNC=N1.Cl | [CAS DataBase Reference]
104075-48-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [RTECS ]
NI6139000 | [HS Code ]
2933.29.2000 | [Toxicity]
LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin) |
| Hazard Information | Back Directory | [Uses]
Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans. | [Biological Activity]
Selective α 2 -adrenergic receptor antagonist (K i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α 2A , α 2B , α 2C , α 1A and α 1B receptors respectively). Brain penetrant. | [Side effects]
A transient hypotensive effect has been observed during the first 10 minutes post-injection of atipamezole hydrochloride. In rare cases, hyperactivity, tachycardia, salivation, atypical vocalization, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination, and defecation may occur. In very rare cases, recurrence of sedation may occur, or the recovery time may not be shortened after administration of atipamezole. In cats, when using low doses to reverse the effects of medetomidine or dexmedetomidine partially, the possibility of hypothermia (even when aroused from sedation) should be guarded against. | [Veterinary Drugs and Treatments]
Atipamezole is labeled for use as a reversal agent for medetomidine
and dexmedetomidine. It potentially
could be useful for reversal
of other alpha2-adrenergic agonists as well (e.g., amitraz, xylazine,
clonidine, tizanidine, brimonidine). | [storage]
Desiccate at RT |
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