| Identification | More | [Name]
Mometasone | [CAS]
105102-22-5 | [Synonyms]
9a,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione
MOMETASONE
MometasoneFuroateBase
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-11,17-dihydroxy-16-methyl-, (11.beta.,16.alpha.)-
Pregna-1,4-diene-3,20-dione, 9,21-dichloro-11,17-dihydroxy-16-methyl-, (11b,16a)-(9CI)
MOMETOSONE FUROATE
Elocon | [EINECS(EC#)]
818-819-4 | [Molecular Formula]
C27H30Cl2O6 | [MDL Number]
MFCD02683426 | [Molecular Weight]
521.43 | [MOL File]
105102-22-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
>211oC (dec.) | [Boiling point ]
586.6±50.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
12.08±0.70(Predicted) | [color ]
White to Pale Beige | [InChI]
InChI=1/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/s3 | [InChIKey]
WOFMFGQZHJDGCX-MCUOXHNDNA-N | [SMILES]
[C@]1(OC(=O)C2OC=CC=2)([C@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C)C(CCl)=O |&1:0,9,12,14,24,26,28,31,r| | [CAS DataBase Reference]
105102-22-5(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
Mometasone is a potent topical corticosteroid. Mometasone has potent antiinflammatory activity and is used in the treatment of dermatological disorders. | [Definition]
ChEBI:Mometasone is an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(1),Delta(4)-steroid, a chlorinated steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug, a dermatologic drug, a vasoconstrictor agent and an anti-allergic agent. It is functionally related to a Delta(1)-progesterone. | [Side effects]
The most common side effects are an unpleasant smell and a dry or sore nose or throat. | [in vivo]
Mometasone (0.1-3 mg/kg; intranasally) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested of 3 mg/kg, and dose-dependently inhibits the allergen-induced increase in Penh in a mouse model of allergic lung inflammation[3]. | [storage]
Store at -20°C |
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