| Identification | Back Directory | [Name]
UCM05 | [CAS]
1094451-90-7 | [Synonyms]
UCM05
G 28UCM
Benzoic acid, 3,4,5-trihydroxy-, 1,1'-(1,3-naphthalenediyl) ester
3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate | [Molecular Formula]
C24H16O10 | [MOL File]
1094451-90-7.mol | [Molecular Weight]
464.38 |
| Hazard Information | Back Directory | [Uses]
G 28UCM is a fatty acid synthase inhibitor with anticancer activity, novel inhibitor of fatty acid synthase with anticancer activity. | [Uses]
UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 μM for SK-BR-3 cells). It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice. UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo. UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.[Cayman Chemical] | [storage]
Store at -20°C |
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Lynnchem
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BOC Sciences
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