| Identification | More | [Name]
Sodium prasterone sulfate | [CAS]
1099-87-2 | [Synonyms]
5-ANDROSTEN-3BETA-OL-17-ONE-3-SULFATE SODIUM
5-ANDROSTEN-3BETA-OL-17-ONE SULFATE SODIUM SALT
5-ANDROSTEN-3-BETA-OL-17-ONE SULPHATE, SODIUM SALT
DEHYDROEPIANDROSTERONE 3-SULFATE SODIUM SALT
DEHYDROEPIANDROSTERONE-3-SULFATE SODIUM SALT HYDRATE
DEHYDROEPIANDROSTERONE SODIUM SULFATE
DEHYDROEPIANDROSTERONE SODIUM SULPHATE
DEHYDROEPIANDROSTERONE SULFATE SODIUM
DEHYDROEPIANDROSTERONE SULFATE SODIUM SALT
DEHYDROISOANDROSTERONE 3-SULFATE SODIUM SALT
DEHYDROISOANDROSTERONE 3-SULFATE, SODIUM SALT HYDRATE
DEHYDROISOANDROSTERONE SULFATE SODIUM
PRASTERONE SODIUM SULFATE
PRASTERONE SULFATE SODIUM SALT
SODIUM DEHYDROEPIANDROSTERONE-3-SULFATE HYDRATE
SODIUM DEHYDROEPIANDROSTERONE SULFATE HYDRATE
SODIUM DEHYDROISOANDROSTERONE-3-SULFATE HYDRATE
3-(sulfooxy)-,sodiumsalt,(3-beta)-androst-5-en-17-on
3-beta-hydroxy-androst-5-en-17-onesterwithsodiumsulfate
androst-5-en-17-one,3-beta-hydroxy-,sulfate(ester),sodiumsalt | [EINECS(EC#)]
214-152-2 | [Molecular Formula]
C19H27NaO5S | [MDL Number]
MFCD00010470 | [Molecular Weight]
390.47 | [MOL File]
1099-87-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
148-149 °C (dec.)(lit.)
| [refractive index ]
10 ° (C=4, MeOH) | [Fp ]
9℃ | [storage temp. ]
-20°C | [solubility ]
methanol: clear to hazy
| [form ]
powder
| [color ]
white to off-white
| [Merck ]
2871 | [Major Application]
clinical testing | [InChIKey]
GFJWACFSUSFUOG-QGVZUKINNA-M | [SMILES]
[C@]12([H])CC[C@]3(C)C(CC[C@@]3([H])[C@]1([H])CC=C1C[C@@H](OS([O-])(=O)=O)CC[C@]21C)=O.[Na+] |&1:0,4,9,11,17,25,r| | [CAS DataBase Reference]
1099-87-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS02,GHS06,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H225-H301+H311+H331-H370 | [Precautionary statements ]
P210-P260-P280-P301+P310-P311 | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R34:Causes burns. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
3
| [RTECS ]
BV8397400 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 | [Toxicity]
dog,LD50,intravaginal,> 500mg/kg (500mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 40, Pg. 444, 1998. |
| Hazard Information | Back Directory | [Description]
Dehydroepiandrosterone sulfate (DHEAS) is a metabolite of dehydroepiandrosterone that is the major secretory product of adrenal glands and is the predominant circulating precursor for active steroid hormones in humans.1 For example, in the fetoplacental-maternal unit, DHEAS acts as the primary precursor for placental estrogen biosynthesis.2 A normal circulating concentration of DHEAS is ~10 μM in young adults and is dramatically increased in some adrenocortical disorders.1 | [Chemical Properties]
White to Off-White Solid | [Uses]
An active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases. | [Definition]
ChEBI: An organic sodium salt that is the monosodium salt of dehydroepiandrosterone sulfate. | [IC 50]
Human Endogenous Metabolite | [References]
[1] JENS NEUNZIG Rita B. Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones.[J]. PLoS ONE, 2014: e89727. DOI: 10.1371/journal.pone.0089727
[2] HO-JIN CHANG. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex.[J]. The Journal of Biological Chemistry, 2004, 279 4: 2689-2696. DOI: 10.1074/jbc.m310446200 |
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