| Identification | More | [Name]
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODIUM SALT | [CAS]
109909-44-6 | [Synonyms]
2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE (SODIUM SALT)
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODIUM SALT
2'-DEOXYCYTIDINE-5'-TRIPHOSPHORIC ACID TRISODIUM SALT
DCTP (SODIUM SALT)
Dctp-Na3
Deoxycytidine-5'-Triphosphoric Acid Trisodium Sal
dCTP,3Na
CYTIDINE 5''-(TETRAHYDROGEN TRIPHOSPHATE), 2''-DEOXY-, TRISODIUM SALT | [Molecular Formula]
C9H13N3Na3O13P3 | [MDL Number]
MFCD00080336 | [Molecular Weight]
533.1 | [MOL File]
109909-44-6.mol |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Water: 10 mg/ml | [form ]
A crystalline solid | [Water Solubility ]
Water: 10 mg/ml | [InChIKey]
WBIPTAOOMJEGQO-JXXKLNQHNA-K | [SMILES]
N1(C=CC(N)=NC1=O)[C@H]1C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])(=O)O)O1.[Na+].[Na+].[Na+] |&1:8,10,12,r| | [CAS DataBase Reference]
109909-44-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Deoxycytidine triphosphate trisodium salt (dCTP trisodium salt or 2′-Deoxycytidine-5′-triphosphate trisodium salt) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate trisodium salt has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
| [Uses]
2′-Deoxycytidine-5′-triphosphate trisodium salt is an activator that has been shown to exhibit anticancer and antiviral activities. It is a novel nucleoside phosphoramidite that is used in the synthesis of DNA, RNA, and other nucleic acids. 2′-Deoxycytidine-5′-triphosphate trisodium salt has been modified by substituting the oxygen atom for a sulfur atom at the 5' position of the sugar moiety. This change makes it resistant to degradation by ribonucleases. 2′-Deoxycytidine-5′-triphosphate trisodium salt has also been shown to act as an inhibitor of human telomerase activity.
| [in vitro]
Assays of thirteen cell lines, derived from mouse lymphomas, myelomas, myeloid tumors, and a mastocytoma, for sensitivity to growth inhibition by 1-β-D-arabinofuranosylcytosine (ara-C) revealed a spectrum between the most and least sensitive which differed 100-fold from each other. An inverse correlation between sensitivity and cellular Deoxycytidine triphosphate (2′-Deoxycytidine-5′-triphosphate, dCTP) content is found, and this suggested that sensitivity of cells might be increased if the dCTP content was lowered during cell exposure to ara-C.
Deoxycytidine triphosphate trisodium salt is a phosphoethanolamine cytidylyltransferase substrate.
| [storage]
-20°C |
|
|