| Identification | Back Directory | [Name]
Demethyl | [CAS]
11041-94-4 | [Synonyms]
Demethyl
norcoclaurine hcl
Higenamine hydrochloride
(+/-)-Higenamine HCl - synthetic
Dacacine base acid and alkali salt
6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline
1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrochloride
6,7-DIHYDROXY-1-(4-HYDROXYBENZYL)-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHL+
6,7-Dihydroxy-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
1,2,3,4-Tetrahydro-1-((4-hydroxyphenyl)methyl)-6,7-isoquinolinediol hydrochloride
_x000D_6，7-Dihydroxy-1-(4-Hydroxybenzyl)-1，2，3，4-tetrahydroisoquinoline Hydrochloride
6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1) | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C16H18ClNO3 | [MDL Number]
MFCD01717353 | [MOL File]
11041-94-4.mol | [Molecular Weight]
307.772 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Pale Beige to Pale Brown | [Stability:]
Hygroscopic |
| Questions And Answer | Back Directory | [Toxicity]
The safety of orally administered higenamine hydrochloride in humans is unknown. During a study of acute toxicity, mice were orally administered the compound at a dose of 2 g per kg of bodyweight. No mice died during the study.In human trials of intravenous higenamine, subjects who received higenamine reported shortness of breath, racing heart, dizziness, headaches, chest tightness. |
| Hazard Information | Back Directory | [Description]
Higenamine is a chemical found in several plants including aconite, Annona squamosa, Nandina domestica (sacred bamboo), and others. HigenaMine Hydrochloride is the hydrochloride form of higenamine. | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata. | [Uses]
Higenamine HCl (norcoclaurine) is a plant-based alkaloid widely used as nutritional supplement in food and beverage industries. | [in vivo]
Higenamine hydrochloride (10 mg/kg; Intraperitoneal injection; Single dose) can significantly reduce the inflammation and infarct size of cerebral ischemic injury caused by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats[2].
Higenamine hydrochloride (0.5-4.5 mg/kg; Single dose) improves cardiac and renal function in rats with cardio-renal syndrome (CRS) and alleviates cardiac and renal fibrosis by targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway in Sprague-Dawley rats[4].
Higenamine hydrochloride (20 mg/kg-30 mg/kg; Intraperitoneal injection; Once daily for 60 days) promotes bone formation and prevents accelerated bone loss in SAMP6 mice[6].
| Animal Model: | Spontaneous osteoporosis SAMP6 mice model[6] | | Dosage: | 10 mg/kg, 20 mg/kg | | Administration: | Intraperitoneal injection (i.p.);Once daily for 60 days | | Result: | Significantly increased the expression of P1NP and OCN (P1NP and OCN are markers of bone formation). |
| [IC 50]
β adrenergic receptor; ASK1 | [storage]
4°C, protect from light |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
jiliang chemicals
|
| Telephone: |
21-62165282 |
| Website: |
http://www.jiliangchem.com |
| Company Name: |
Shanghai Everchem Co., Ltd
|
| Telephone: |
86-29-81325371 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList5555/0_EN.htm |
|