| Identification | More | [Name]
Boldine | [CAS]
476-70-0 | [Synonyms]
1,10-DIMETHOXY-2,9-DIHYDROXYAPORPHINE
2 6-DIHYDROXY-3 5-DIMETHOXYAPORPHIN
2,9-DIHYDROXY-1,10-DIMETHOXYAPORPHINE
(+)-BOLDINE
BOLDINE
BOLDO STANDARD EXTRACT
(+)-(s)-boldine
(s)-boldine
(s)-yl
1,10-dimethoxy-6a-alpha-aporphine-2,9-diol
1,10-dimethoxy-6a-alpha-aporphine-9-diol
4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth
4h-dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl
boldin
boldine--chloroform
BOLDINE(RG)
2,9-Dihydroxy-1,10-dimethoxyaporphine, Boldine
(-)-6-Methyl-1,10-dimethoxy-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
(6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol | [EINECS(EC#)]
207-509-9 | [Molecular Formula]
C19H21NO4 | [MDL Number]
MFCD00135040 | [Molecular Weight]
327.37 | [MOL File]
476-70-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
162-164 °C | [Boiling point ]
465.27°C (rough estimate) | [density ]
1.2223 (rough estimate) | [refractive index ]
1.5000 (estimate) | [storage temp. ]
2-8°C | [solubility ]
Acetonitrile (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly) | [form ]
neat | [pka]
9.75±0.20(Predicted) | [color ]
Yellow to Dark Brown | [Merck ]
13,1316 | [BRN ]
94036 | [Major Application]
food and beverages
forensics and toxicology
veterinary | [InChI]
1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1 | [InChIKey]
LZJRNLRASBVRRX-ZDUSSCGKSA-N | [SMILES]
COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O | [LogP]
0.837 (est) | [Uses]
boldine is attributed with strong anti-oxidant properties. It has also demonstrated an ability to protect against uVB rays. Boldine is a constituent of the boldo plant (Peumus boldus Mol.) native to Chile, and is found in the plant’s leaves and bark. | [CAS DataBase Reference]
476-70-0(CAS DataBase Reference) | [EPA Substance Registry System]
476-70-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S1:Keep locked up .
S20:When using, do not eat or drink .
S24/25:Avoid contact with skin and eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
1544 | [WGK Germany ]
3
| [RTECS ]
CE0750000
| [TSCA ]
TSCA listed | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29399990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata. | [Definition]
ChEBI: Boldine is an aporphine alkaloid. | [in vivo]
Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways[3].
| Animal Model: | DSS-induced mice model[3] | | Dosage: | 50 mg/kg | | Administration: | p.o. | | Result: | Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO)
Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA)
Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.
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