110657-98-2

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110657-98-2 Structure

Identification	Back Directory
[Name] LXA5
[CAS] 110657-98-2
[Synonyms] LXA5 Lipoxin A5,Lipoxin A-5 ZZMKOZNTEJVKRY-YJUORNCYSA-N 5S,6R,15S-TRIHYDROXY-7E,9E,11Z,13E,17Z-EICOSAPENTAENOIC ACID 7,9,11,13,17-Eicosapentaenoic acid, 5,6,15-trihydroxy-, (5S,6R,7E,9E,11Z,13E,15S,17Z)-
[Molecular Formula] C20H30O5
[MDL Number] MFCD11976895
[MOL File] 110657-98-2.mol
[Molecular Weight] 350.45

Chemical Properties	Back Directory
[Boiling point ] 591.3±50.0 °C(Predicted)
[density ] 1.112±0.06 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[solubility ] DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml
[pka] 4.67±0.10(Predicted)

Hazard Information	Back Directory
[Description] Lipoxin A₅ (LXA₅) is produced by enzymatic transformation of EPA by leukocytes. LXA₅ slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA₄ and LXB₄. However, LXA₅ does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA₄ and LXB₄.
[Uses] Lipoxin A5 is a metabolite of EPA with effects similar to LXA4 and LXB4.
[References] [1] PATRICK Y-K WONG Bing L Richard Hughes. Lipoxene: A new group of trihydroxy pentaenes of eicosapentaenoic acid derived from porcine leukocytes[J]. Biochemical and biophysical research communications, 1985, 126 2: Pages 763-772. DOI: 10.1016/0006-291x(85)90250-5 [2] GREGORY L. STAHL . Pharmacologic profile of lipoxins A5 and B5: new biologically active eicosanoids[J]. European journal of pharmacology, 1989, 163 1: Pages 55-60. DOI: 10.1016/0014-2999(89)90394-4

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