| Identification | More | [Name]
Fmoc-D-leucine | [CAS]
114360-54-2 | [Synonyms]
9-FLUORENYLMETHOXYCARBONYL-D-LEUCINE
FMOC-D-BETA-LEU-OH
FMOC-D-LEU
FMOC-D-LEUCINE
FMOC-D-LEU-OH
N-(9-FLUORENYLMETHOXYCARBONYL)-D-LEUCINE
N-9-FLUORENYLMETHYLOXYCARBONYL-D-LEUCINE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-LEUCINE
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-LEUCINE
N-ALPHA-FMOC-D-LEUCINE
FMOC-D-LEU-OH 99+%
n-[(9h-fluoren-9-ylmethoxy)carbonyl]-d-leucine
n-fmoc-d-leucine
N-9-FLUORENYLMETHYLOXYCARBONYL-D-LEUCINE(FMOC-D-LEU-OH)
FMOC-D-LEUCINE extrapure
Nα-(9-Fluorenylmethyloxycarbonyl)-D-leucine ,98% | [EINECS(EC#)]
252-662-7 | [Molecular Formula]
C21H23NO4 | [MDL Number]
MFCD00062957 | [Molecular Weight]
353.41 | [MOL File]
114360-54-2.mol |
| Questions And Answer | Back Directory | [Synthesis]
FMOC-D-leucine is prepared by reacting 9-fluorenemethoxycarbonyl chloride with leucine in the presence of a base. This method is simple to operate, has mild reaction conditions, high yield, and wide applicability. The synthetic reaction formula of FMOC-D-leucine is shown in the figure below:  |
| Chemical Properties | Back Directory | [Melting point ]
155°C | [Boiling point ]
559.8±33.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [refractive index ]
25 ° (C=1, DMF) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder to crystal | [pka]
3.91±0.21(Predicted) | [color ]
White to Almost white | [Optical Rotation]
Consistent with structure | [Water Solubility ]
Insoluble in water. | [Detection Methods]
T,NMR,Rotation | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m1/s1 | [InChIKey]
CBPJQFCAFFNICX-LJQANCHMSA-N | [SMILES]
C(O)(=O)[C@@H](CC(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O | [CAS DataBase Reference]
114360-54-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline where the condensation between L-tryptophan methyl ester and N-Fmoc-D-leucine in the presence of EDC as coupling agent afforded the corresponding L-Trp-D-Leu dipeptide. | [Definition]
ChEBI: Fmoc-D-Leu-OH is a leucine derivative. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis |
|
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