| Identification | More | [Name]
1-(2-THIAZOLYLAZO)-2-NAPHTHOL | [CAS]
1147-56-4 | [Synonyms]
1-(2-THIAZOLYLAZO)-2-NAPHTHOL
2-(2-HYDROXY-1-NAPHTHYLAZO)THIAZOLE
TAN
1-(2’-Thiazolylazo)-β-naphtho
1-(2-thiazolylazo)-2-naphthaleno
1-(2-thiazolylazo)-2-Naphthalenol
1-(thiazol-2-ylazo)-2-naphthol
1-(2'-Thiazolylazo)-β-naphthol
TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals]
2-(2-Hydroxy-1-naphthylazo)thiazole, TAN
1-(Thiazole-2-ylazo)-2-naphthol
1-(Thiazole-2-ylazo)naphthalene-2-ol
1-[(Thiazole-2-yl)azo]-2-naphthol
Nitrilotantalum(III) | [EINECS(EC#)]
214-555-3 | [Molecular Formula]
C13H9N3OS | [MDL Number]
MFCD00021611 | [Molecular Weight]
255.3 | [MOL File]
1147-56-4.mol |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
2927.00.5000 |
| Hazard Information | Back Directory | [Description]
ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress. | [Uses]
1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice. | [in vivo]
NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. [1]. | [storage]
Store at -20°C | [References]
1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|