| Identification | More | [Name]
2-Methyl-4-Isothiazolin-3-one | [CAS]
2682-20-4 | [Synonyms]
1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA
2-METHYL-3(2H)-ISOTHIAZOLONE
2-METHYL-4-ISOTHIAZOLIN-3-ONE
2-METHYL-4-ISOTHIAZOLINE-3-ONE
3,4,4 TRICHLOROCARBANILIDE
3,4,4'-TRICHLOROCARBANILIDE
3,4,4'-TRICHLORODIPHENYLUREA
CUTISAN
N-(3,4-DICHLOROPHENYL)-N'-(4-CHLOROPHENYL)UREA
N-(4-CHLOROPHENYL)-N-(3,4-DICHLOROPHENYL)-UREA
N-METHYL-3-OXODIHYDRO ISOTHIAZOLE
TCC
TRICHLOROCARBANILIDE
TRICLOCARBAN
2-methyl-3(2h)-isothiazolon
Isothiazolone,2-methyl-
Methylisothiazolinone
Skycide 100
2-methyl-2H-isothiazol-3-one
2-Methylisothiazolin-3-one | [EINECS(EC#)]
220-239-6 | [Molecular Formula]
C4H5NOS | [MDL Number]
MFCD00013254 | [Molecular Weight]
115.15 | [MOL File]
2682-20-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
254-256 °C(lit.)
| [Boiling point ]
bp0.03 93° | [density ]
1.25 (14% aq.) | [vapor pressure ]
<0.1 mm Hg ( 25 °C)
| [storage temp. ]
2-8°C | [solubility ]
Chloroform, Ethyl Acetate | [form ]
neat | [pka]
-2.03±0.20(Predicted) | [color ]
Yellow | [Water Solubility ]
489g/L at 20℃ | [BRN ]
606203 | [Contact allergens]
MI is generally associated with MCI, in Kathon® CG, MCI/MI, and Euxyl® K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis. | [InChIKey]
BEGLCMHJXHIJLR-UHFFFAOYSA-N | [LogP]
-0.486 at 20℃ | [Uses]
methylisothiazolinone is a preservative. | [CAS DataBase Reference]
2682-20-4(CAS DataBase Reference) | [NIST Chemistry Reference]
3(2H)-isothiazolone, 2-methyl-(2682-20-4) | [EPA Substance Registry System]
2682-20-4(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Low melting Solid | [Uses]
2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c
ontaining solution. | [Uses]
A potent biocide useful for controlling microbial growth | [Definition]
ChEBI: A 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM. | [Preparation]
Methylisothiazolinone (MIT)is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide:
NCSCH=CHC(O)NHCH3?SCH=CHC(O)NCH3+HCN
| [Hazard]
Methylisothiazolinone(MIT)is allergenic and cytotoxic, and this has led to some concern over its use.A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT.
| [Side effects]
Early on, dermatitis may occur only on part of the exposed skin. Common patterns include: hand dermatitis，perianal dermatitis, perivulval dermatitis, napkin dermatitis, facial dermatitis, eyelid swelling, and scalp dermatitis.
Later, more extensive and severe whole-body contact dermatitis may occur in very sensitive people. | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Hazard Codes ]
N,C | [Risk Statements ]
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R50:Very Toxic to aquatic organisms.
R43:May cause sensitization by skin contact.
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24:Avoid contact with skin .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
2
| [RTECS ]
FE1250000
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29349990 | [Hazardous Substances Data]
2682-20-4(Hazardous Substances Data) |
| Questions And Answer | Back Directory | [Description]
Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of isothiazolinones.
Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, methylisothiazolinone is allergenic. It is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.
| [Uses]
2-Methyl-4-isothiazolin-3-one, or MIT as it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations. | [Safety]
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.
| [References]
[1] http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/methylisothiazolinone/
[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122
[3] https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_G-58_1-Oct-98.pdf
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