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2682-20-4

2682-20-4 Structure

2682-20-4 Structure
IdentificationMore
[Name]

2-Methyl-4-Isothiazolin-3-one
[CAS]

2682-20-4
[Synonyms]

1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA
2-METHYL-3(2H)-ISOTHIAZOLONE
2-METHYL-4-ISOTHIAZOLIN-3-ONE
2-METHYL-4-ISOTHIAZOLINE-3-ONE
3,4,4 TRICHLOROCARBANILIDE
3,4,4'-TRICHLOROCARBANILIDE
3,4,4'-TRICHLORODIPHENYLUREA
CUTISAN
N-(3,4-DICHLOROPHENYL)-N'-(4-CHLOROPHENYL)UREA
N-(4-CHLOROPHENYL)-N-(3,4-DICHLOROPHENYL)-UREA
N-METHYL-3-OXODIHYDRO ISOTHIAZOLE
TCC
TRICHLOROCARBANILIDE
TRICLOCARBAN
2-methyl-3(2h)-isothiazolon
Isothiazolone,2-methyl-
Methylisothiazolinone
Skycide 100
2-methyl-2H-isothiazol-3-one
2-Methylisothiazolin-3-one
[EINECS(EC#)]

220-239-6
[Molecular Formula]

C4H5NOS
[MDL Number]

MFCD00013254
[Molecular Weight]

115.15
[MOL File]

2682-20-4.mol
Chemical PropertiesBack Directory
[Melting point ]

254-256 °C(lit.)
[mp ]

254-256 °C(lit.)
[Boiling point ]

bp0.03 93°
[density ]

1.25 (14% aq.)
[vapor pressure ]

<0.1 mm Hg ( 25 °C)
[Contact allergens]

MI is generally associated with MCI, in Kathon® CG, MCI/MI, and Euxyl® K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.
[InChIKey]

BEGLCMHJXHIJLR-UHFFFAOYSA-N
[CAS DataBase Reference]

2682-20-4(CAS DataBase Reference)
[NIST Chemistry Reference]

3(2H)-isothiazolone, 2-methyl-(2682-20-4)
[EPA Substance Registry System]

2682-20-4(EPA Substance)
Hazard InformationBack Directory
[Chemical Properties]

Yellow Low melting Solid
[Uses]

2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.
[Uses]

A potent biocide useful for controlling microbial growth
[Definition]

ChEBI: A 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM.
Safety DataBack Directory
[Hazard Codes ]

N,C
[Risk Statements ]

R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R50:Very Toxic to aquatic organisms.
R43:May cause sensitization by skin contact.
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
[Safety Statements ]

S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24:Avoid contact with skin .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 3077 9/PG 3
[WGK Germany ]

2
[RTECS ]

FE1250000
[HazardClass ]

8
[PackingGroup ]

III
[HS Code ]

29349990
Questions And AnswerBack Directory
[Description]

Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of  isothiazolinones.
Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, methylisothiazolinone is allergenic. It is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.
[References]

[1] http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/methylisothiazolinone/
[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122
[3] https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_G-58_1-Oct-98.pdf
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

2682-20-4(sigmaaldrich)
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