| Identification | Back Directory | [Name]
SPDB | [CAS]
115088-06-7 | [Synonyms]
LKB
SPDB
SPDB crosslinker
N-Succinimidyl-4-(2-pyridyldithio)butanoate
5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate
2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate
4-(Pyridin-2-yldisulfanyl)butyric acid N-Hydroxysuccinimide ester
Butanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C13H14N2O4S2 | [MOL File]
115088-06-7.mol | [Molecular Weight]
326.39 |
| Chemical Properties | Back Directory | [Melting point ]
47-48 °C | [Boiling point ]
480.1±55.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Ethanol:100.0(Max Conc. mg/mL);306.39(Max Conc. mM) | [form ]
<47°C Solid,>48°C Liquid | [pka]
1.89±0.19(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs)[1]. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing.
Bioconjug Chem, 2015 Nov 18, 26(11):2261-78. DOI:10.1021/acs.bioconjchem.5b00430 |
|
|