| Identification | Back Directory | [Name]
N[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide Hydrochloride | [CAS]
1158347-73-9 | [Synonyms]
BML 280
VU0285655-1
3-Quinolinecarboxamide, N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)ethyl]-
N-{2-[4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decan-8-yl]ethyl}quinoline-3-carboxaMide
N[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxaMide Chloride
N-{2-[4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO(4.5)DECAN-8-YL]ETHYL}QUINOLINE-3-CARBOXAMIDE;VU0285655-1
N[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]quinoline-3-carboxamide Hydrochloride | [Molecular Formula]
C25H27N5O2 | [MDL Number]
MFCD22416859 | [MOL File]
1158347-73-9.mol | [Molecular Weight]
429.51 |
| Chemical Properties | Back Directory | [Boiling point ]
768.2±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Off-white solid. | [pka]
13.65±0.46(Predicted) | [color ]
White to off-white | [InChI]
1S/C25H27N5O2/c31-23(20-16-19-6-4-5-9-22(19)27-17-20)26-12-15-29-13-10-25(11-14-29)24(32)28-18-30(25)21-7-2-1-3-8-21/h1-9,16-17H,10-15,18H2,(H,26,31)(H,28,32) | [InChIKey]
WJOCDBUFEUKYNI-UHFFFAOYSA-N | [SMILES]
O=C(C1=CN=C(C=CC=C2)C2=C1)NCCN(CC3)CCC43N(C5=CC=CC=C5)CNC4=O |
| Hazard Information | Back Directory | [Uses]
A novel compound showing PLD (Phospholipase D) inhibitory activity. | [Biological Activity]
VU0285655-1 or N-2-[4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decan-8-yl]ethyl quinoline-3-carboxamide is a phospholipase D-2 (PLD2) inhibitor. It promotes autophagy in colorectal cancer cells. | [IC 50]
PLD2; PLD1; IL-1β; IL-8 |
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