1162264-07-4

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1162264-07-4 Structure

Identification	Back Directory
[Name] LY2623091
[CAS] 1162264-07-4
[Synonyms] LY2623091 LY2623091 (LY-2623091 Urea, N-[5-[(E)-(3-fluorodibenz[b,e]oxepin-11(6H)-ylidene)methyl]-1,3-dihydro-1-[(1R)-1-methyl-2-(4-morpholinyl)ethyl]-2H-benzimidazol-2-ylidene]-, [N(E)]-
[Molecular Formula] C30H30FN5O3
[MDL Number] MFCD26406001
[MOL File] 1162264-07-4.mol
[Molecular Weight] 527.6

Hazard Information	Back Directory
[Uses] LY2623091 is a mineralocorticoid receptor antagonist for the treatment of refractory hypertension. LY2623091 exhibits CYP3A4-dependent clearance and synergistic effects with CYP3A4 inhibitors[1][2].
[References] [1] Dickinson G L, et al. Physiologically based pharmacokinetic modeling to understand the observed drug–drug interaction of LY2623091 with CYP3A inhibitors itraconazole and diltiazem[J]. International journal of Pharmacokinetics, 2017, 2(4): 233-245. [2] Kocienski P. Synthesis of LY2623091[J]. Synfacts, 2017, 13(05): 0451.

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