| Identification | More | [Name]
Hydrocortisone sodium succinate | [CAS]
125-04-2 | [Synonyms]
11b,17a,21-trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate sodium salt
11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM-POTASSIUM SALT
11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT
4-PREGNEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT
4-PREGNEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-HEMISUCCINATE SODIUM
CORTISOL 21-HEMISUCCINATE SOD
CORTISOL 21-HEMISUCCINATE SODIUM-POTASSIUM SALT
CORTISOL 21-HEMISUCCINATE SODIUM SALT
HYDROCORTISONE 21-HEMISUCCINATE SODIUM
HYDROCORTISONE 21-HEMISUCCINATE SODIUM SALT
HYDROCORTISONE HEMISUCCINATE SODIUM SALT
HYDROCORTISONE-HYDROGEN SUCCINATE SODIUM SALT
HYDROCORTISONE SODIUM SUCCINATE
a-hydrocort
buccalsone
corlan
cortisol,21-(hydrogensuccinate),monosodiumsalt
cortisol,succinate,sodiumsalt
cortisol21-sodiumsuccinate
cortisolhemisuccinatesodiumsalt | [EINECS(EC#)]
204-725-5 | [Molecular Formula]
C46H64Na2O14 | [MDL Number]
MFCD00069472 | [Molecular Weight]
886.97 | [MOL File]
125-04-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
169.0-171.2° | [storage temp. ]
−20°C
| [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [color ]
White to Off-White | [biological source]
synthetic (organic) | [Water Solubility ]
H2O: 50mg/mL | [InChIKey]
HHZQLQREDATOBM-CODXZCKSSA-M | [SMILES]
[C@]12(C)C[C@@H]([C@]3([H])[C@@]4(C)CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@]2(O)C(=O)COC(=O)CCC([O-])=O)O.[Na+] |&1:0,3,4,6,16,18,22,r| | [CAS DataBase Reference]
125-04-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 μM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells. | [Uses]
Hydrocortisone sodium succinate is a derivative of the glucocorticoid Hydrocortisone (H714615). Hydrocortisone Hemisuccinate Sodium is used as an anti-inflammatory agent. Hydrocortisone sodium succinate is widely used in the treatment of asthma, endocrine disorders, dermatological disorders, allergic states, etc.
| [Definition]
ChEBI:Hydrocortisone Sodium Succinate is an organic molecular entity. | [Brand name]
A-Hydrocort (Abbott); A-Hydrocort (Hospira); Solu-Cortef
(Pharmacia & Upjohn). | [General Description]
Hydrocortisone for use in epithelial and endothelial adherent cell culture applications. | [Clinical Use]
#N/A | [Synthesis]
A method of preparing sodium hydrocortisone succinate, characterized in that it comprises the steps of:
(1) reacting hydrocortisone succinate with a buffer solution in a polar solvent at 0-80°C for 1-4 h, controlling the pH 5-8, and after the r | [Drug interactions]
Potentially hazardous interactions with other drugs
Aldesleukin: avoid concomitant use.
Antibacterials: metabolism accelerated by rifampicin;
metabolism possibly inhibited by erythromycin;
concentration of isoniazid possibly reduced.
Anticoagulants: efficacy of coumarins and
phenindione may be altered.
Antiepileptics: metabolism accelerated by
carbamazepine, fosphenytoin, phenobarbital,
phenytoin and primidone.
Antifungals: increased risk of hypokalaemia with
amphotericin - avoid; metabolism possibly inhibited
by itraconazole and ketoconazole.
Antivirals: concentration possibly increased by ritonavir.
Ciclosporin: rare reports of convulsions in patients
on ciclosporin and high-dose corticosteroids.
Cobicistat: concentration of hydrocortisone possibly
increased - increased risk of adrenal suppression.
Diuretics: enhanced hypokalaemic effects of
acetazolamide, loop diuretics and thiazide diuretics.
Vaccines: high dose corticosteroids can impair
immune response to vaccines - avoid concomitant
use with live vaccines. | [Metabolism]
Hydrocortisone is metabolised in the liver and most
body tissues to hydrogenated and degraded forms such as
tetrahydrocortisone and tetrahydrocortisol.
These are excreted in the urine, mainly conjugated as
glucuronides, with a very small proportion of unchanged
hydrocortisone. | [storage]
Store at -20°C |
|
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J & K SCIENTIFIC LTD.
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Spectrum Chemical Manufacturing Corp.
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Sigma-Aldrich
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Jinan Putubio Tech Co., Ltd.
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