| Identification | Back Directory | [Name]
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH | [CAS]
117399-93-6 | [Synonyms]
et-3
EDN3
HSCR4
human,rat
ET-3, HUMAN
ENDOTHELIN-3
Rat endothelin-3
ET-3 (HUMAN, RAT)
Endothelin 3【rat】
Human endothelin-3
ET-3, HUMAN AND RAT
ENDOTHELIN-3, HUMAN
Endothelin 3【canine】
Endothelin 3【rabbit】
CTCFTYKDKECVYYCHLDIIW
ET-3 (HUMAN, RAT, PIG)
ENDOTHELIN 3 HUMAN, RAT
Endothelin 3 (Rat,Human)
Endothelin 3 (huMan)(9CI)
ENDOTHELIN-III, HUMAN, RAT
ENDOTHELIN 3, HUMAN AND RAT
ENDOTHELIN-3 (HUMAN, RAT, PIG)
Endothelin 3 (mouse intestine)
ENDOTHELIN 3, HUMAN, RAT, 50 UG*
ET-3 (HUMAN, MOUSE, RABBIT, RAT)
M.W. 2643.04 C121H168N26O33S4
Endothelin 3 huMan, ratEndothelin
Anti-EDN3 antibody produced in rabbit
ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT)
ENDOTHELIN-3 (HUMAN, RAT, PORCINE, RABBIT)
ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT)
Endothelin 3, human, rat, ≥97% (HPLC), powder
ANTI-EDN3 (C-TERM) antibody produced in rabbit
19: PN: WO2007112069 SEQID: 10 claimed protein
CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11)
Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem
Endothelin-3 (huMan, Mouse, rabbit, rat)
ET-3 (huMan, Mouse, rabbit, rat)
CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP
CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)
CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)
33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv.
Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11
L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) | [Molecular Formula]
C121H168N26O33S4 | [MDL Number]
MFCD00076378 | [MOL File]
117399-93-6.mol | [Molecular Weight]
2643.04 |
| Chemical Properties | Back Directory | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
H2OPeptide Solubility and Storage Guidelines:1.??Calculate the length of the peptide.2.??Calculate the overall charge of the entire peptide according to the following table:3.??Recommended solution: | [form ]
powder
| [color ]
white
| [biological source]
rabbit | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfide bridge: Cys1-Cys15, Cys3-Cys11) | [InChIKey]
OQGZWNZGVYLIFX-XKIQDWPYSA-N |
| Hazard Information | Back Directory | [Uses]
Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors. | [General Description]
Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon. | [Biochem/physiol Actions]
Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma. | [in vivo]
Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity[3]. | [storage]
Store at -20°C |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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