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144602-02-8

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144602-02-8 Structure

144602-02-8 Structure
IdentificationBack Directory
[Name]

IRL-1038
[CAS]

144602-02-8
[Synonyms]

IRL-1038
IRL-1038, HUMAN
ENDOTHELIN-1 (11-21)
ENDOTHELIN-1 (11-21), HUMAN
M.W. 1409.70 C68H94N14O15S2
Endothelin-1 (11-21) IRL-1038
[CYS11, CYS15]ENDOTHELIN-I (11-21)
[CYS11-CYS15]-ENDOTHELIN-1 (11-21)
Endothelin-1 (11-21) trifluoroacetate salt
CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP
H-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
11-21-Endothelin 1 (swine reduced), cyclic (11→15)-disulfide
CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP (DISULFIDE BRIDGE CYS1-CYS5)
Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge Cys11-Cys15)
[Molecular Formula]

C68H92N14O15S2
[MDL Number]

MFCD00214658
[MOL File]

144602-02-8.mol
[Molecular Weight]

1409.67
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
[solubility ]

Soluble to 1 mg/ml in 20% acetonitrile
[form ]

Solid
[Sensitive ]

Light Sensitive
[Sequence]

Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge:Cys1-Cys5)
Hazard InformationBack Directory
[Uses]

IRL 1038 is an endothelin B receptor selective antagonist with a Ki of 6-11 nM[1].
[storage]

Desiccate at -20°C
[References]

[1] Urade Y, et al. An endothelin B receptor-selective antagonist: IRL 1038, [Cys11-Cys15]-endothelin-1(11-21). FEBS Lett. 1992 Oct 12;311(1):12-6. doi: 10.1016/0014-5793(92)81355-p. DOI:10.1016/0014-5793(92)81355-p
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